20.500.12556/DKUM-83702 Indukcija poroda s Propess vaginalnim sistemom v primerjavi z indukcijo poroda s Prostin vaginalno tableto pri predčasnem razpoku plodovih ovojev v terminu A Randomised Controlled Trial Comparing Induction of Labour with the Propess Vaginal System to the Prostin Vaginal Tablet in Premature Rupture of Membranes at Term Cilj raziskave je bil primerjati perinatalni izid in porodne intervale po sprožitvi poroda z vaginalno tableto Prostin v primerjavi z vaginalnim sistemom Propess pri nosečnicah s predčasnim razpokom plodovih ovojev (PROM) v terminu. Zasnova: vzporedna randomizirana kontrolirana raziskava z računalniško ustvarjeno tabelo za izbiro zdravila. Kraj izvedbe: Univerzitetni klinični center Maribor, Slovenija. Preiskovanke: Skupno 205 zdravih nosečnic z enoplodno nosečnostjo v glavični vstavi s PROM-om v terminu. Raziskava: sprožitev poroda z vaginalnim sistemom Propess (raziskovalna skupina) v primerjavi s tabletami Prostin (kontrolna skupina). Glavni cilji: stopnja neuspešnih sprožitev, zapleti pri porodu, časovni intervali med PROM-om, sprožitvijo, začetkom aktivne faze in porodom. Rezultati: Prostin so prejele 104 nosečnice, Propess pa 101 nosečnica. Neuspešne sprožitve v skupinah Prostin in Propess so bile 8/104 (7,7 %) oziroma 5/101 (5,0 %) (p = 0,80). Nepravilnosti pri porodu so bile redke in primerljive med skupinama. Delež carskih rezov v skupini Prostin in Propess je bil 4/96 (4,2 %) oziroma 6/96 (6,3 %). Časovni intervali poroda so bili med skupinami primerljivi. Sklepi: Pri nosečnostih v terminu s PROM-om je vaginalni sistem Propess varna in učinkovita izbira za sprožitev poroda. Aim: To compare the perinatal outcome and delivery intervals after the induction of labour with the Prostin vaginal tablet versus the Propess vaginal system in pregnant women with term-PROM. Design: One centre paralleled randomised controlled trial with a computer-generated table to allocate treatments. Setting: University Medical Centre in Slovenia. Participants: A total of 205 singleton healthy pregnant women with term-PROM. Intervention: Induction of labour with the Propess vaginal system (intervention group) versus Prostin tablets (control group). Main outcomes: The rate of failed inductions, complications in labour, time intervals between the PROM, induction, the beginning of the active phase, and delivery. Results: A total of 104 patients received Prostin, and 101 patients received Propess. Induction failure rates in the Prostin and the Propess groups were 8/104 (7.7%) and 5/101 (5.0%), respectively (p = 0.80). Delivery abnormalities were uncommon and comparable across the groups. The rates of caesarean sections in the Prostin and Propess groups were 4/96 (4.2%) and 6/96 (6.3%), respectively. The delivery intervals were comparable across the groups. Conclusions: In term-PROM pregnancies, the Propess vaginal system is a safe and effective option for inducing labour. prezgodnji razpok mehurja sprožitev poroda randomizirana kontrolirana raziskava Propess vaginalni sistem Prostin vaginalna tableta premature rupture of membranes at term induction of labour a randomised controlled trial Propess vaginal system Prostin vaginal tablet true true false Slovenski jezik Angleški jezik Doktorsko delo/naloga 2023-01-24 20:48:34 2023-07-20 13:41:13 2023-07-21 03:05:27 0000-00-00 00:00:00 2023 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 159380739 DOK_Anzeljc_Veronika_2023.pdf DOK_Anzeljc_Veronika_2023.pdf 1 B3C894975DB2D8D490B7D56DFA178E6C 2b411cbd8803236a8baee617b2aa91ec0a7fca1f6f8ce2be78d8a72fb4c97f5e e6f6b1d9-20f6-11ee-aa7e-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=168731 Medicinska fakulteta 0 0 0