20.500.12556/DKUM-84161 Algorithmic linearization improves Syringe-based extrusion in elastic systems using Hydrogel-based materials Accuracy and precision are essential in extrusion-based material handling such as three-dimensional (3D) bioprinting. However, the elasticity of components, backlash, variability of nozzle and cartridge shapes, etc. can lead to unpredictable printing results, which is further complicated by the wide range of rheologically diverse materials and complex sample designs. To address this issue, we present an algorithmic approach to compensate for the discrepancies between piston motion and material extrusion in syringe-based extrusion systems. This approach relies on cyclical, iterative optimization through rapid piston movements, which are adjusted based on extrusion analysis. In this work we establish a general theoretical framework for extrusion and link the rheological properties of prepared hydrogels with shear rates in a typical bioprinting process. The determined properties are compared with the success of the developed algorithm to modify machine instructions for precise material deposition of short, interrupted lines, as well as multi-layered scaffold structures. Overall, our approach provides a means of improving the accuracy and precision of complex extrusion-based bioprinting systems, without prior knowledge of set-up or material properties, making it highly versatile and suitable for a wide range of applications, particularly when the combined set-up and material properties are too complex for solely predictive approaches. 3D bioprinting syringe extrusion optimization algorithm 3D biotisk iztiskanje brizge optimizacija algoritmi true true true Elsevier Angleški jezik Slovenski jezik https://www.sciencedirect.com/journal/materials-and-design Članek v reviji 2023-04-21 14:44:47 2023-04-21 14:44:47 2024-05-08 10:10:03 0000-00-00 00:00:00 2023 0 0 13 str. Vol. 229, [article no.] 111884 May 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-01-06 0000-00-00 2023-05-01 602:004.9 150063107 10.1016/j.matdes.2023.111884 0264-1275 1-s2.0-S026412752300299X-main.pdf 1-s2.0-S026412752300299X-main.pdf 1 3331FD64E1796C5FF8A555946B7F52E7 d50dd10dae1cc3245cb677199865fd7f61ec65691fbe3dc7c3e9d93d07a3144d 1a8d5abc-e043-11ed-b0e1-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=166929 https://www.sciencedirect.com/science/article/pii/S026412752300299X?via%3Dihub 0 c6c70251-f19d-11ee-a24b-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=177821 Fakulteta za strojništvo Fakulteta za kemijo in kemijsko tehnologijo Medicinska fakulteta 0 0 0