20.500.12556/DKUM-84865 A system pharmacology multi-omics approach toward uncontrolled pediatric asthma There is a clinical need to identify children with poor asthma control as early as possible, to optimize treatment and/or to find therapeutic alternatives. Here, we present the “Systems Pharmacology Approach to Uncontrolled Pediatric Asthma” (SysPharmPediA) study, which aims to establish a pediatric cohort of moderate-to-severe uncontrolled and controlled patients with asthma, to investigate pathophysiological mechanisms underlying uncontrolled moderate-to-severe asthma in children on maintenance treatment, using a multi-omics systems medicine approach. In this multicenter observational case–control study, moderate-to-severe asthmatic children (age; 6–17 years) were included from four European countries (Netherlands, Germany, Spain, and Slovenia). Subjects were classified based on asthma control and number of exacerbations. Demographics, current and past patient/family history, and clinical characteristics were collected. In addition, systems-wide omics layers, including epi(genomics), transcriptomics, microbiome, proteomics, and metabolomics were evaluated from multiple samples. In all, 145 children were included in this cohort, 91 with uncontrolled (median age = 12 years, 43% females) and 54 with controlled asthma (median age = 11.7 years, 37% females). The two groups did not show statistically significant differences in age, sex, and body mass index z-score distribution. Comprehensive information and diverse noninvasive biosampling procedures for various omics analyses will provide the opportunity to delineate underlying pathophysiological mechanisms of moderate-to-severe uncontrolled pediatric asthma. This eventually might reveal novel biomarkers, which could potentially be used for noninvasive personalized diagnostics and/or treatment. pediatric asthma uncontrolled asthma omics systems medicine otroška astma nekontrolirana astma medicina true false true Angleški jezik Slovenski jezik Znanstveno delo 2023-08-02 09:05:56 2023-08-02 09:05:56 2023-08-03 03:08:15 0000-00-00 00:00:00 2021 0 0 str. 1-16 iss. 6 Vol. 11 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2021-01-01 616.248 65569795 10.3390/jpm11060484 2075-4426 A_System_Pharmacology_Multi-Om-Abdel-Aziz-2021.pdf A_System_Pharmacology_Multi-Om-Abdel-Aziz-2021.pdf 1 116B45F829BB40FF3424D991C89229BB 8d0eb676f6cff68cea1358b87e95773661d6d20545bd5970dc47e74fd027bb28 6544faad-3103-11ee-b6b4-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=169158 https://www.mdpi.com/2075-4426/11/6/484 0 6de06594-3103-11ee-b6b4-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=169159 Medicinska fakulteta 0 0 0