20.500.12556/DKUM-84947 Skeletal muscle uncoupling proteins in mice models of obesity Obesity and accompanying type 2 diabetes are among major and increasing worldwide problems that occur fundamentally due to excessive energy intake during its expenditure. Endotherms continuously consume a certain amount of energy to maintain core body temperature via thermogenic processes, mainly in brown adipose tissue and skeletal muscle. Skeletal muscle glucose utilization and heat production are significant and directly linked to body glucose homeostasis at rest, and especially during physical activity. However, this glucose balance is impaired in diabetic and obese states in humans and mice, and manifests as glucose resistance and altered muscle cell metabolism. Uncoupling proteins have a significant role in converting electrochemical energy into thermal energy without ATP generation. Different homologs of uncoupling proteins were identified, and their roles were linked to antioxidative activity and boosting glucose and lipid metabolism. From this perspective, uncoupling proteins were studied in correlation to the pathogenesis of diabetes and obesity and their possible treatments. Mice were extensively used as model organisms to study the physiology and pathophysiology of energy homeostasis. However, we should be aware of interstrain differences in mice models of obesity regarding thermogenesis and insulin resistance in skeletal muscles. Therefore, in this review, we gathered up-to-date knowledge on skeletal muscle uncoupling proteins and their effect on insulin sensitivity in mouse models of obesity and diabetes. uncoupling protein skeletal muscle insulin diabetes obesity fiziologija človeka patofiziologija diabetes debelost beljakovine skeletne mišice laboratorijske miši true false true Angleški jezik Slovenski jezik Znanstveno delo 2023-08-10 11:22:30 2023-08-10 11:22:31 2023-08-11 03:35:57 0000-00-00 00:00:00 2022 0 0 str. 1-22 art. 259 no. 3 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-01-01 612 107486467 10.3390/metabo12030259 2218-1989 https://www.mdpi.com/2218-1989/12/3/259 1 70198121-375f-11ee-8a7c-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=169369 Skeletal_Muscle_Uncoupling_Protein-Bombek-2022.pdf Skeletal_Muscle_Uncoupling_Protein-Bombek-2022.pdf 1 18E01A881531BF168F1CC6AE5EA4876B 3ab521eefe1e79dfb1ff69a91d1949b8cf8dedea1b1728b91c29658655e1a6c9 d98267e7-375f-11ee-8a7c-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=169370 Medicinska fakulteta 0 0 0