20.500.12556/DKUM-85059 Določanje težkih kovin z metodo ICP-MS v vzorcih najbolj prodajanih prehranskih dodatkov v času epidemije Covid-19 in ocena kontaminacije magistrsko delo Determination of heavy metals by the method ICP-MS in samples of top-selling dietary supplements during the Covid-19 epidemic and assessment of contamination Uporaba prehranskih dodatkov je v zadnjih desetletjih po vsem svetu v porastu. Še posebej v času pandemije Covid-19 so prehranski dodatki postali izjemno pogost del vsakodnevne prehrane ljudi. S trendom naraščajoče uporabe in zaradi težav z regulacijo, nadzorom, kakovostjo ter učinkovitostjo prehranskih dodatkov se je pojavila potreba po analizi in ugotavljanju, ali prehranski dodatki morda vsebujejo nedovoljene količine zdravju škodljivih spojin, vključno s težkimi kovinami. V magistrskem delu smo analizirali vsebnost kovin v 17 komercialno dostopnih vzorcih prehranskih dodatkov. Vse vzorce prehranskih dodatkov smo razvrstili v 6 skupin - dodatki na osnovi: 1) vitaminov/mineralov; 2) izvlečkov rastlin; 3) zeolitov; 4) alg; 5) gob in 6) omega-3 maščobnih kislin. Koncentracije 13 kovin (Ag, As, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Na, Pb, Zn) smo določili z masno spektrometrijo z induktivno sklopljeno plazmo (ICP-MS). V določenih vzorcih smo tudi merili vsebnost živega srebra z atomsko absorpcijsko spektrometrijo s toplotno razgradnjo in amalgamacijo (TDA-AAS). Določili smo, da je en vzorec vseboval svinec nad mejno vrednostjo (izmerjena presežena vrednost je bila v vzorcu prehranskega dodatka na osnovi zeolita in je znašala 11,7 mg/kg). Rezultati za vsebnost ostalih kovin so bili v skladu z vrednostmi, predpisanimi z nacionalno in tujo zakonodajo, ali predpisanimi s strani različnih institucij. Z magistrsko nalogo smo poudarili pomembnost preverjanja kakovosti prehranskih dodatkov, najprej zaradi zagotavljanja njihove neonesnaženosti, nato pa tudi zaradi preprečitve zavajajočih trditev o prehranskih dodatkih in zaščite potrošnikov. The use of dietary supplements has been on the rise all over the world in recent decades, and dietary supplements have become an extremely common part of people's daily diet, especially during the Covid-19 pandemic. With the growing trend of use and problems with regulation, control, quality and effectiveness of dietary supplements, there has been a need to analyze and determine whether dietary supplements may contain impermissible amounts of harmful compounds, including heavy metals. In the master's thesis, we determined the metal content in 17 commercially available samples of dietary supplements. We classified all samples of dietary supplements into 6 groups - supplements based on: 1) vitamins/minerals; 2) plant extracts; 3) zeolites; 4) algae; 5) mushrooms and 6) omega-3 fatty acids. The concentrations of 13 metals (Ag, As, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Na, Pb, Zn) were determined by inductively coupled plasma mass spectrometry (ICP-MS). Mercury content was also determined in certain samples by thermal decomposition and amalgamation atomic absorption spectrometry (TDA-AAS). It was determined that one sample contained lead above the limit value (the measured exceeded value was in a sample of a zeolite-based dietary supplement and was 11,7 mg/kg). The results for the content of other metals were in accordance with the values prescribed by national and foreign legislation or prescribed by various institutions. With this research, we emphasized the importance of verification the quality of dietary supplements, first of all to ensure their non-contamination, but also to prevent misleading claims about nutritional supplements and to protect consumers. prehranski dodatki Covid-19 težke kovine esencialne kovine onesnaženost ICP-MS TDA-AAS dietary supplements Covid-19 heavy metals essential metals contamination ICP-MS TDA-AAS true true false [V. Jakovljević] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2023-08-17 11:44:03 2023-09-11 08:04:31 2023-10-05 03:13:24 0000-00-00 00:00:00 2023 0 Maribor 0 Maribor 1 spletni vir (1 datoteka PDF (XI, 84 f.)) 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 543.632.495(043.2) (043.2) 166938115 MAG_Jakovljevic_Vanja_2023.pdf MAG_Jakovljevic_Vanja_2023.pdf 1 07D62A3AC32C8BEC3B9B6279BF3C41C8 0fb296b563921a413092c9932a01d3a6bc49ee2398a7f2c3066d8cbd33c644e8 575b86e2-4e3f-11ee-9575-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=171835 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0