20.500.12556/DKUM-85066 Bioactive coatings with anti-osteoclast therapeutic agents for bone implant enhanced compliance and prolonged implant life The use of therapeutic agents that inhibit bone resorption is crucial to prolong implant life, delay revision surgery, and reduce the burden on the healthcare system. These therapeutic agents include bisphosphonates, various nucleic acids, statins, proteins, and protein complexes. Their use in systemic treatment has several drawbacks, such as side effects and insufficient efficacy in terms of concentration, which can be eliminated by local treatment. This review focuses on the incorporation of osteoclast inhibitors (antiresorptive agents) into bioactive coatings for bone implants. The ability of bioactive coatings as systems for local delivery of antiresorptive agents to achieve optimal loading of the bioactive coating and its release is described in detail. Various parameters such as the suitable concentrations, release times, and the effects of the antiresorptive agents on nearby cells or bone tissue are discussed. However, further research is needed to support the optimization of the implant, as this will enable subsequent personalized design of the coating in terms of the design and selection of the coating material, the choice of an antiresorptive agent and its amount in the coating. In addition, therapeutic agents that have not yet been incorporated into bioactive coatings but appear promising are also mentioned. From this work, it can be concluded that therapeutic agents contribute to the biocompatibility of the bioactive coating by enhancing its beneficial properties. bioactive coatings implants bone resorption osteolysis osteoclats inhibitors bioaktivni premazi vsadki resorpcija kosti osteoliza zaviralci osteoklastov true false true Angleški jezik Slovenski jezik Znanstveno delo 2023-08-17 13:33:24 2023-08-17 13:33:24 2023-08-18 03:09:54 0000-00-00 00:00:00 2022 0 0 15 str. Vol. 176 Feb. 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-02-01 2021-08-10 577 92991491 10.1016/j.phrs.2022.106060 1043-6618 Bioactive_coatings_with_anti-osteo-Bjelic-2022.pdf Bioactive_coatings_with_anti-osteo-Bjelic-2022.pdf 1 2AD98120AD450261C5517961B13C830F 2f4146571c2bbe5529e5be077cc696d23e26338792c7b18341f5e36d4c0f5081 213c65f2-3cf2-11ee-af21-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=169667 https://www.sciencedirect.com/science/article/pii/S1043661822000056?via%3Dihub 0 28f2944d-3cf2-11ee-af21-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=169668 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0