20.500.12556/DKUM-85109 Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain a transdiagnostic multimodal meta-analysis of structural and functional MRI studies Major depressive disorder (MDD), anxiety disorders (ANX), and chronic pain (CP) are closely-related disorders with both high degrees of comorbidity among them and shared risk factors. Considering this multi-level overlap, but also the distinct phenotypes of the disorders, we hypothesized both common and disorder-specific changes of large-scale brain systems, which mediate neural mechanisms and impaired behavioral traits, in MDD, ANX, and CP. To identify such common and disorder-specific brain changes, we conducted a transdiagnostic, multimodal meta-analysis of structural and functional MRI-studies investigating changes of gray matter volume (GMV) and intrinsic functional connectivity (iFC) of large-scale intrinsic brain networks across MDD, ANX, and CP. The study was preregistered at PROSPERO (CRD42019119709). 320 studies comprising 10,931 patients and 11,135 healthy controls were included. Across disorders, common changes focused on GMV-decrease in insular and medial-prefrontal cortices, located mainly within the so-called default-mode and salience networks. Disorder-specific changes comprised hyperconnectivity between defaultmode and frontoparietal networks and hypoconnectivity between limbic and salience networks in MDD; limbic network hyperconnectivity and GMV-decrease in insular and medial-temporal cortices in ANX; and hypoconnectivity between salience and default-mode networks and GMV-increase in medial temporal lobes in CP. Common changes suggested a neural correlate for comorbidity and possibly shared neuro-behavioral chronification mechanisms. Disorder-specific changes might underlie distinct phenotypes and possibly additional disorder-specific mechanisms. human threat behaviour major depressive disorder anxiety disorders chronic pain structural MRI functional MRI človeško vedenje ob nevarnosti velika depresivna motnja kronična bolečina strukturni fMR funkcijski fMR true true true Angleški jezik Slovenski jezik Članek v reviji 2023-08-18 13:39:24 2023-08-18 13:39:24 2024-02-27 15:02:29 0000-00-00 00:00:00 2022 0 0 str. 1071-1080 47 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-01-01 616.89 102554115 10.1038/s41386-022-01271-y 0893-133X https://www.nature.com/articles/s41386-022-01271-y.pdf 1 e1eef2f2-3dbb-11ee-8efa-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=169769 Common_and_specific_large-scale_br-Brandl-2022.pdf Common_and_specific_large-scale_br-Brandl-2022.pdf 1 16870D8FF6FCC34BFDDE4D4DD7068D3B ed86a2c6e5b1d1b1abed894a044331d99744dfd7f8d8283054ec9f19233c4551 c41121c1-3dbc-11ee-8efa-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=169772 Filozofska fakulteta 0 0 0