20.500.12556/DKUM-85214 Neuropilin (NRPs) related pathological conditions and their modulators Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane glycoprotein distributed in many human body tissues as a (co)receptor for a variety of different ligands. In addition to its physiological role, it is also associated with various pathological conditions. Recently, NRP1 has been discovered as a coreceptor for the SARS-CoV-2 viral entry, along with ACE2, and has thus become one of the COVID-19 research foci. However, in addition to COVID-19, the current review also summarises its other pathological roles and its involvement in clinical diseases like cancer and neuropathic pain. We also discuss the diversity of native NRP ligands and perform a joint analysis. Last but not least, we review the therapeutic roles of NRP1 and introduce a series of NRP1 modulators, which are typical peptidomimetics or other small molecule antagonists, to provide the medicinal chemistry community with a state-of-the-art overview of neuropilin modulator design and NRP1 druggability assessment. neuropilins computer-aided drug design in silico drug design receptor modulator design peptidomimetics small-molecule antagonists cancer COVID-19 neuropathic pain neuropilini peptidi true false true MDPI Angleški jezik Slovenski jezik https://www.mdpi.com/journal/ijms © 2022 by the authors Znanstveno delo 2023-08-22 14:47:01 2023-08-22 14:47:01 2025-04-09 13:47:31 0000-00-00 00:00:00 2022 0 0 23 str. Št. 15 Letn. 23 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2022-06-24 2022-07-27 2022-07-29 577 118216451 10.3390/ijms23158402 1422-0067 Neuropilin_(NRPs)_Related_Pathologic-Broz-2022.pdf Neuropilin_(NRPs)_Related_Pathologic-Broz-2022.pdf 1 FFF99CA8217077C2D8FF0BBE5D423850 218716402755f41c3fd845b80c587d7e949f70f45f390090e0162016cd9c56f9 1933496d-40eb-11ee-8474-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=170045 https://www.mdpi.com/1422-0067/23/15/8402 0 2177927d-40eb-11ee-8474-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=170046 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0