20.500.12556/DKUM-85256 Peripheral blood transcriptome in breast cancer patients as a source of less invasive immune biomarkers for personalized medicine, and implications for triple negative breast cancer Transcriptome studies of peripheral blood cells can advance our understanding of the systemic immune response to the presence of cancer and the mechanisms underlying cancer onset and progression. This enables the identification of novel minimally invasive immune biomarkers for early cancer detection and personalized cancer management and may bring forward new immunotherapy options. Recent blood gene expression analyses in breast cancer (BC) identified distinct patient subtypes that differed in the immune reaction to cancer and were distinct from the clinical BC subtypes, which are categorized based on expression of specific receptors on tumor cells. Introducing new BC subtypes based on peripheral blood gene expression profiles may be appropriate, since it may assist in BC prognosis, the identification of patients likely to benefit from immunotherapy, and treatment efficacy monitoring. Triple-negative breast cancer (TNBC) is an aggressive, heterogeneous, and difficult-to-treat disease, and identification of novel biomarkers for this BC is crucial for clinical decision-making. A few studies have reported TNBC-enriched blood transcriptional signatures, mostly related to strong inflammation and augmentation of altered immune signaling, that can differentiate TNBC from other classical BC subtypes and facilitate diagnosis. Future research is geared toward transitioning from expression signatures in unfractionated blood cells to those in immune cell subpopulations. triple negative breast cancer transcriptome peripheral blood PBMC gene expression immune biomarker trojni negativni rak dojke transkriptom periferna kri PBMC izražanje genov biomarkerji true false true Angleški jezik Slovenski jezik Znanstveno delo 2023-08-23 13:51:08 2023-08-23 14:01:36 2023-08-24 03:07:42 0000-00-00 00:00:00 2022 0 0 str. 1-21 Št. 3 Letn. 14 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-01-01 618.19-006 94899715 10.3390/cancers14030591 2072-6694 Peripheral_Blood_Transcriptome_i-Celesnik-2022.pdf Peripheral_Blood_Transcriptome_i-Celesnik-2022.pdf 1 616993E41B421AF14BADEB86410B6F00 4688566b1013833343f37a44008709a6050bb4a29eebbde8a367206f16bbf703 baab0b1d-41ac-11ee-9a51-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=170166 https://www.mdpi.com/2072-6694/14/3/591 1 5a42515f-41ab-11ee-9a51-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=170163 https://doi.org/10.3390/cancers14030591 1 5c0757e2-41ab-11ee-9a51-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=170164 Fakulteta za kemijo in kemijsko tehnologijo Medicinska fakulteta 0 0 0