20.500.12556/DKUM-86600 Vpliv pandemije covid-19 na porabo antibiotikov in pojav okužb z bakterijami, odpornimi proti antibiotikom Impact of the covid-19 pandemic on the consumption of antibiotics and the emergence of infections with antibiotic-resistant bacteria Povzetek Uvod: Pandemija covid-19 je vplivala na celotni zdravstveni sistem s potrebo po spremembi organizacije dela. Poslabšala je razmere v bolnišnicah z vidika pojava bolnišničnih okužb, kolonizacij in njihovega prenosa. Pri sočasni okužbi z virusom SARS-CoV2 se je zaradi sekundarne bakterijske okužbe uvajala antibiotična terapija. Metode: Raziskava je temeljila na kvantitativni metodologiji. Preučevali smo vpliv pandemije covid-19 na porabo antibiotikov in pojav bolnišničnih okužb, kolonizacij z VOB. Za vzorec empiričnega dela raziskave smo uporabili bolnišnico v severovzhodni Sloveniji. Podatke smo spremljali pred in med pandemijo covid-19 ter jih statistično obdelali z uporabo Mann-Whitney U Testa in Spearmanovega korelacijskega testa. Rezultati: V času pandemije covid-19 se je povečala poraba antibiotikov in pojav bolnišničnih okužb, kolonizacij, vendar razlika ni statistično pomembna. Poraba antibiotikov v letu 2018 je znašala 49,400 DDD/100 BOD, leta 2019 je 47,965 DDD/100 BOD, leta 2020 je 51,020 DDD/100 BOD in leta 2021 je poraba na letni ravni znašala 54,705 DDD/100 BOD. Povečala se je pojavnost ESBL, VRE, CRE, CPE, CRAb in premo sorazmerno zmanjšala pojavnost MRSA in CRPs in CP. Zaključek: Pomankanje rezervnih skupin antibiotikov in vse večji porast bolnišničnih okužb postaja vedno večji izziv. Abstract Introduction: The covid-19 pandemic has affected the entire healthcare system with the need to change the organization of work. It worsened the situation in hospitals from the point of view of the occurrence of nosocomial infections, colonization and their transmission. In case of co-infection with the SARS-CoV2 virus, antibiotic therapy was introduced due to secondary bacterial infection. Methods: The research was based on quantitative methodology. We studied the impact of the covid-19 pandemic on the consumption of antibiotics and the occurrence of nosocomial infections and colonization with VOB. For the sample of the empirical part of the research, we used a hospital in north-eastern Slovenia. We monitored the data before and during the covid-19 pandemic and processed them statistically using the Mann-Whitney U Test and the Spearman correlation test. Results: During the covid-19 pandemic, the consumption of antibiotics and the occurrence of nosocomial infections increased, but the difference was not statistically significant. The consumption of antibiotics in 2018 was 49,400 DDD/100 BOD, in 2019 it was 47,965 DDD/100 BOD, in 2020 it was 51,020 DDD/100 BOD and in 2021 the annual consumption was 54,705 DDD/100 BOD. The incidence of ESBL, VRE, CRE, CPE, CRAb increased and the incidence of MRSA and CRPs and CP decreased in direct proportion. Conclusion: The lack of reserve groups of antibiotics and the growing increase in nosocomial infections are becoming an increasing challenge. covid-19 antibiotiki odpornost bolnišnične okužbe izolacijski ukrepi covid-19 antibiotics resistance nosocomial infections isolation measures true false false [K. Kranjec] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2023-12-20 08:34:38 2024-03-26 15:14:19 2024-07-25 04:09:37 0000-00-00 00:00:00 2024 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-036.21:615.33(043.2) 190403843 MAG_Kranjec_Konrad_2024.pdf MAG_Kranjec_Konrad_2024.pdf 1 BF69D370CE2DD7EEE367233B0CB5CB71 724c481bdc84b2707be9b8aa7c06f9eb2f396cbaf7f516e6113a35176120881e 7436405f-49b8-11ef-934d-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=181771 Fakulteta za zdravstvene vede 0 0 0