20.500.12556/DKUM-87081 Ultra-high-risk gestational choriocarcinoma of the ovary associated with ectopic pregnancy Gestational choriocarcinoma of the ovary is an exceptionally rare and highly aggressive tumor. Preoperative diagnosis of extrauterine choriocarcinoma is difficult due to nonspecific clinical presentation and its resemblance to ectopic pregnancy. Without molecular genetic analysis, it is not possible to reliably differentiate gestational from non-gestational choriocarcinoma. Here, we present a case of a 44-year-old woman who presented to our emergency department with complaints of pelvic pain, vaginal bleeding, and amenorrhea. Because of a recent history of conservatively managed ectopic pregnancy, the patient underwent emergency laparoscopy. Right-sided salpingo-oophorectomy was performed due to intraoperatively suspected ovarian ectopic pregnancy. Histopathology results revealed the diagnosis of ovarian choriocarcinoma of possible gestational origin. It was classified as FIGO stage IV and WHO ultra-high-risk, and she underwent multi-agent chemotherapy without major complications. She has remained in complete remission after a 12-month follow-up. Considering the rarity of this diagnosis, we conducted a literature review including all published cases of suspected gestational choriocarcinomas of the ovary. We conclude that due to the rarity of this entity, preoperative differentiating between ovarian ectopic pregnancy and ovarian choriocarcinoma is extremely challenging, and without molecular genetic analysis, it is not possible to identify the genetic origin of the tumor. ovarian choriocarcinoma gestational trophoblastic neoplasia hariokarcinom jajčnika gestacijska trofoblastna neoplazija true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2024-02-16 09:30:54 2024-02-21 10:50:01 2024-02-22 03:10:28 0000-00-00 00:00:00 2023 0 0 Str. 2217-2226 Št. 2 Letn. 30 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2022-12-30 2023-02-07 2023-02-11 618.1 141695747 10.3390/curroncol30020171 1718-7729 Malovrh-2023-Ultra-High-Risk_Gestational_Chori.pdf Malovrh-2023-Ultra-High-Risk_Gestational_Chori.pdf 1 BD9025E2B782781AFE996755FF0BB3DF 2946e62007ae61ea8bf7bda6dc1764b5a80767f6ea350c89bd87a13056ceaa11 5b0b56d0-d09e-11ee-bf60-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=176335 https://doi.org/10.3390/curroncol30020171 1 b3fb1838-cca5-11ee-b5a0-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=176203 Medicinska fakulteta 0 0 0