20.500.12556/DKUM-87121 Hybrid polylactic-acid–pectin aerogels synthesis, structural properties, and drug release Wound-dressing materials often include other materials stimulating wound healing. This research describes the first formulation of biodegradable hybrid aerogels composed of polylactic acid and pectin. The prepared hybrid material showed a highly porous structure with a surface area of 166 +/- 22.6 m(2)center dot g(-1). The addition of polylactic acid may have decreased the surface area of the pure pectin aerogel, but it improved the stability of the material in simulated body fluid (SBF). The pure pectin aerogel showed a high swelling and degradation ratio after 3 h. The addition of the polylactic acid prolonged its stability in the simulated body fluid from 24 h to more than one week, depending on the amount of polylactic acid. Biodegradable aerogels were loaded with indomethacin and diclofenac sodium as model drugs. The entrapment efficiencies were 63.4% and 62.6% for indomethacin and diclofenac sodium, respectively. Dissolution of both drugs was prolonged up to 2 days. Finally, sodium percarbonate and calcium peroxide were incorporated into the bioaerogels as chemical oxygen sources, to evaluate oxygen generation for potential wound healing applications. hybrid aerogels bioaerogel pectin polylactic acid wound healing hibridni aerogeli bioaerogeli pektin polimlečna kislina celjenje ran true false true MDPI Angleški jezik Slovenski jezik https://www.mdpi.com/journal/polymers Članek v reviji 2024-02-20 15:48:17 2024-02-20 15:57:09 2024-05-10 08:14:08 0000-00-00 00:00:00 2023 0 0 Str. 1-12 Št. 2 Letn. 15 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2022-12-23 2023-01-10 2023-01-12 66.02 137625603 10.3390/polym15020407 2073-4360 Horvat-2023-Hybrid_Polylactic-Acid-Pectin_Aero.pdf Horvat-2023-Hybrid_Polylactic-Acid-Pectin_Aero.pdf 1 5BB389A1675DFD1DF1544DE28B3F7232 dfa6e39d04357d5d88fbd06b6cd5f0083871ce900011628c57e2029dee9b1f09 22043dde-d000-11ee-b227-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=176322 https://www.mdpi.com/2073-4360/15/2/407 0 2e36310f-d000-11ee-b227-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=176323 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0