20.500.12556/DKUM-88252 Učinkovitost zdravljenja sindroma policističnih jajčnikov z metforminom Efficacy of metformin treatment in polycysticovary syndrome preučevanje celic beta v Langerhansovih otočkih Metformin is an oral antidiabetic drug with potentially beneficial effects in patients with polycystic ovary syndrome (PCOS). Different pharmacological responses to metformin have been reported in PCOS patients, which may be attribut able to various clinical, biochemical, genetic and other factors. Here, we have outlined a short review of the results from current clinical studies on metformin efficacy in PCOS patients. Additionally, preliminary results from a retrospective pharmacogenetic study by our group on a sample of Slovene PCOS patients are presented. Pharmacogenetics is an emerging science that should provide options for individualized medicine, the future of healthcare. Metformin je peroralni antidiabetik, potencialno učinkovit tudi v terapiji bolnic s sindromom policističnih jajčnikov (PCOS). Med bolnicami s PCOS prihaja do opaznih razlik v farmakološkem odzivu na metformin, kar je verjetno posledica kliničnih, biokemijskih, genetskih in drugih dejavnikov. V prispevku navajamo kratek pregled ugotovitev dosedanjih kliničnih študij učinkovitosti zdravljenja bolnic s PCOS z metforminom ter hkrati povzemamo preliminarne rezultate retrospektivne farmakogenetske študije na vzorcu slovenskih bolnic s PCOS. Sodobno znanje farmakogenetike si počasi, a vztrajno utira pot v klinično prakso ter postaja pomemben segment obravnave bolnikov in eden od temeljev osebne medicine medicine prihodnosti. sindrom policističnih jajčnikov metformin farmakogenetika osebna medicina polycystic ovary syndrome metformin pharmacogenetics personalized medicine true true false Angleški jezik Slovenski jezik Znanstveno delo 2024-04-12 09:54:21 2024-04-12 09:54:21 2026-03-19 13:00:09 0000-00-00 00:00:00 2013 0 0 str. 13-20 št. 2 Letn. 6 2013 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2013-01-01 618.11-085 1165228 1855-5640 http://www.actamedbio.mf.uni-mb.si/01_11id_amb_87_12.pdf 1 e03f3b9c-f8a1-11ee-a0d6-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=178381 01.pdf 01.pdf 1 10B9B61AA4F13D80AE7E1B1C3C4DBD7E e952f9defc3c2d2c569cf8a8b594e232359574bbeacd4e9c5a303fe1060014b6 4ab8821b-f8a2-11ee-a0d6-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=178382 Medicinska fakulteta Acta medico-biotechnica 0 0 0