20.500.12556/DKUM-88404 Multilayer methacrylate-based wound dressing as a therapeutic tool for targeted pain relief This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief. wound dressings pain relief superparamagnetic nanoparticles methacrylate obloge za rane lajšanje bolečin superparamagnetni nanodelci metakrilat true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2024-04-19 13:24:44 2024-04-19 13:41:46 2024-04-20 03:28:44 0000-00-00 00:00:00 2023 0 0 Str. 1-21 Št. 6, št. članka 2361 Letn. 16 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-03-01 2023-03-13 2023-03-15 615.4 146598147 10.3390/ma16062361 1996-1944 Zidaric-2023-Multilayer_Methacrylate-Based_Wou.pdf Zidaric-2023-Multilayer_Methacrylate-Based_Wou.pdf 1 01C6E305C1E5492519547215E7897E20 1ba7900a0f4d64ada9c5814b9e81c38da37ff7805b1c1f8c04c547dc484aaca3 1cb7fe1e-fe41-11ee-8dad-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=178779 https://doi.org/10.3390/ma16062361 0 6d277c94-fe3f-11ee-8dad-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=178778 Medicinska fakulteta 0 0 0