20.500.12556/DKUM-88638 Modeling the amino acid effect on glucagon secretion from pancreatic alpha cells Type 2 Diabetes Mellitus (T2DM) is a burdensome problem in modern society, and intensive research is focused on better understanding the underlying cellular mechanisms of hormone secretion for blood glucose regulation. T2DM is a bi-hormonal disease, and in addition to 100 years of increasing knowledge about the importance of insulin, the second hormone glucagon, secreted by pancreatic alpha cells, is becoming increasingly important. We have developed a mathematical model for glucagon secretion that incorporates all major metabolic processes of glucose, fatty acids, and glutamine as the most abundant postprandial amino acid in blood. In addition, we consider cAMP signaling in alpha cells. The model predictions quantitatively estimate the relative importance of specific metabolic and signaling pathways and particularly emphasize the important role of glutamine in promoting glucagon secretion, which is in good agreement with known experimental data. diabetes hormone secretion glucose amino acid cAMP sladkorna bolezen izločanje hormonov glukoza aminokisline true true true MDPI Angleški jezik Slovenski jezik Članek v reviji 2024-05-17 03:19:46 2024-05-21 10:10:27 2024-05-22 03:34:50 0000-00-00 00:00:00 2022 0 0 str. 1-15 iss. 4 Vol. 12 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2022-03-21 2022-04-12 2022-04-13 616.379-008.64 105003779 10.3390/metabo12040348 2218-1989 RAZ_Zmazek_Jan_2022.pdf RAZ_Zmazek_Jan_2022.pdf 1 B3C5A831D6A69D4C4193582455CA247E 6dc5810b4cf5faa4d00723cfe8d8196c870b918059d0b779baa4a103af254c71 162597ec-174a-11ef-84d7-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=179544 https://www.mdpi.com/2218-1989/12/4/348 0 c3f11786-1749-11ef-84d7-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=179543 Fakulteta za naravoslovje in matematiko Fakulteta za elektrotehniko, računalništvo in informatiko Pedagoška fakulteta Medicinska fakulteta 0 0 0