20.500.12556/DKUM-89024 The role of anaplerotic metabolism of glucose and glutamine in insulin secretion a model approach We propose a detailed computational beta cell model that emphasizes the role of anaplerotic metabolism under glucose and glucose-glutamine stimulation. This model goes beyond the traditional focus on mitochondrial oxidative phosphorylation and ATP-sensitive K+ channels, highlighting the predominant generation of ATP from phosphoenolpyruvate in the vicinity of KATP channels. It also underlines the modulatory role of H2O2 as a signaling molecule in the first phase of glucose-stimulated insulin secretion. In the second phase, the model emphasizes the critical role of anaplerotic pathways, activated by glucose stimulation via pyruvate carboxylase and by glutamine via glutamate dehydrogenase. It particularly focuses on the production of NADPH and glutamate as key enhancers of insulin secretion. The predictions of the model are consistent with empirical data, highlighting the complex interplay of metabolic pathways and emphasizing the primary role of glucose and the facilitating role of glutamine in insulin secretion. By delineating these crucial metabolic pathways, the model provides valuable insights into potential therapeutic targets for diabetes. mathematical models pancreatic beta cell pyruvate-malate cycle matematični modeli beta celica trebušne slinavke piruvat-malatni cikel true true true Angleški jezik Slovenski jezik Članek v reviji 2024-06-06 03:44:53 2024-06-06 10:33:54 2024-06-07 03:17:47 0000-00-00 00:00:00 2024 0 0 16 str. [article no.] 107270 Vol. 311 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-01-31 2024-05-22 2024-05-23 612.015.3 197803779 10.1016/j.bpc.2024.107270 0301-4622 RAZ_Grubelnik_Vladimir_2024.pdf RAZ_Grubelnik_Vladimir_2024.pdf 1 9BE6724E24593D0E4240748D08D5F628 1ffbb5735bf0c87c297a527b7d6a3fc904d559a9dcf2d5bf90297a3fbced5c8a 6d35660e-23df-11ef-9cfe-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=180257 https://www.sciencedirect.com/science/article/pii/S0301462224000991?via%3Dihub 0 0e7e03bd-23df-11ef-9cfe-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=180256 Fakulteta za elektrotehniko, računalništvo in informatiko Fakulteta za naravoslovje in matematiko Medicinska fakulteta Pedagoška fakulteta 0 0 0