20.500.12556/DKUM-89079 Lipoprotein(a) as a risk factor in a cohort of hospitalised cardiovascular patients A retrospective clinical routine data analysis Lipoprotein(a) (Lp(a)) is a well-recognised risk factor for ischemic heart disease (IHD) and calcific aortic valve stenosis (AVS). Methods: A retrospective observational study of Lp(a) levels (mg/dL) in patients hospitalised for cardiovascular diseases (CVD) in our clinical routine was performed. The Lp(a)-associated risk of hospitalisation for IHD, AVS, and concomitant IHD/AVS versus other non-ischemic CVDs (oCVD group) was assessed by means of logistic regression. Results: In total of 11,767 adult patients, the association with Lp(a) was strongest in the IHD/AVS group (eβ = 1.010, p < 0.001), followed by the IHD (eβ = 1.008, p < 0.001) and AVS group (eβ = 1.004, p < 0.001). With increasing Lp(a) levels, the risk of IHD hospitalisation was higher compared with oCVD in women across all ages and in men aged ≤75 years. The risk of AVS hospitalisation was higher only in women aged ≤75 years (eβ = 1.010 in age < 60 years, eβ = 1.005 in age 60–75 years, p < 0.05). Conclusions: The Lp(a)-associated risk was highest for concomitant IHD/AVS hospitalisations. The differential impact of sex and age was most pronounced in the AVS group with an increased risk only in women aged ≤75 years. acute myocardial infarction aortic valve stenosis atherosclerosis cardiovascular diseases cardiovascular risk ischemic heart disease lipoprotein(a) postmenopausal women ateroskleroza kardiovaskularne bolezni bolezni srca true false true MDPI Angleški jezik Slovenski jezik https://www.mdpi.com/journal/jcm © 2023 by the authors Članek v reviji 2024-06-12 10:06:53 2024-06-12 10:06:55 2024-06-13 03:19:02 0000-00-00 00:00:00 2023 0 0 [1]-10 str. issue 9, [article no.] 3220 Vol. 12 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-03-02 2023-04-27 2023-04-29 616.1 151715843 10.3390/jcm12093220 2077-0383 jcm-12-03220-v2.pdf jcm-12-03220-v2.pdf 1 9F6C7E699DCEEE836FCAAA0546EC8D1B 16d950575d875638643b4a9ce6f4a4ddc1ffe25c1112a0e172956a02fa80f53d 245c5ac0-2893-11ef-ae3f-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=180441 https://www.mdpi.com/2077-0383/12/9/3220 1 be99415d-2892-11ef-ae3f-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=180440 Fakulteta za elektrotehniko, računalništvo in informatiko 0 0 0