20.500.12556/DKUM-89336 What do stimulated beta cells have in common with cancer cells? This study investigates the metabolic parallels between stimulated pancreatic beta cells and cancer cells, focusing on glucose and glutamine metabolism. Addressing the significant public health challenges of Type 2 Diabetes (T2D) and cancer, we aim to deepen our understanding of the mechanisms driving insulin secretion and cellular proliferation. Our analysis of anaplerotic cycles and the role of NADPH in biosynthesis elucidates their vital functions in both processes. Additionally, we point out that both cell types share an antioxidative response mediated by the Nrf2 signaling pathway, glutathione synthesis, and UCP2 upregulation. Notably, UCP2 facilitates the transfer of C4 metabolites, enhancing reductive TCA cycle metabolism. Furthermore, we observe that hypoxic responses are transient in beta cells post-stimulation but persistent in cancer cells. By synthesizing these insights, the research may suggest novel therapeutic targets for T2D, highlighting the shared metabolic strategies of stimulated beta cells and cancer cells. This comparative analysis not only illuminates the metabolic complexity of these conditions but also emphasizes the crucial role of metabolic pathways in cell function and survival, offering fresh perspectives for tackling T2D and cancer challenges. reductive metabolism succinate true true true Angleški jezik Slovenski jezik Članek v reviji 2024-07-04 04:22:01 2024-08-06 10:14:17 2024-08-08 03:22:01 0000-00-00 00:00:00 2024 0 0 11 str. [article no.] ǂ105257 Vol. 242 Aug. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-03-26 2024-06-11 2024-06-12 616.379 200576771 10.1016/j.biosystems.2024.105257 0303-2647 RAZ_Marhl_Marko_2024.pdf RAZ_Marhl_Marko_2024.pdf 1 7A60D95B8598390C9F261D08F35C7E27 b37b7edb2218661acd2c22cc60cab5a1a349fae80143fc2a3810022ce618ab6f 43cb3ef2-548e-11ef-b534-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=182076 https://www.sciencedirect.com/science/article/pii/S0303264724001424?via%3Dihub 0 5e68d2d3-548e-11ef-b534-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=182078 Medicinska fakulteta Pedagoška fakulteta Fakulteta za naravoslovje in matematiko 0 0 0