20.500.12556/DKUM-89351 Novel methacrylate-based multilayer nanofilms with incorporated FePt-based nanoparticles and the anticancer drug 5-fluorouracil for skin cancer treatment Despite medical advances, skin-associated disorders continue to pose a unique challenge to physicians worldwide. Skin cancer is one of the most common forms of cancer, with more than one million new cases reported each year. Currently, surgical excision is its primary treatment; however, this can be impractical or even contradictory in certain situations. An interesting potential alternative could lie in topical treatment solutions. The goal of our study was to develop novel multilayer nanofilms consisting of a combination of polyhydroxyethyl methacrylate (PHEMA), polyhydroxypropyl methacrylate (PHPMA), sodium deoxycholate (NaDOC) with incorporated superparamagnetic iron–platinum nanoparticles (FePt NPs), and the potent anticancer drug (5-fluorouracil), for theranostic skin cancer treatment. All multilayer systems were prepared by spin-coating and characterised by atomic force microscopy, infrared spectroscopy, and contact angle measurement. The magnetic properties of the incorporated FePt NPs were evaluated using magnetisation measurement, while their size was determined using transmission electron microscopy (TEM). Drug release performance was tested in vitro, and formulation safety was evaluated on human-skin-derived fibroblasts. Finally, the efficacy for skin cancer treatment was tested on our own basal-cell carcinoma cell line. nanomaterials bimodal therapy topical skin treatmen magnetic nanoparticles thin films skin cancer methacrylates nanomateriali bimodalno zdravljenje lokalno zdravljenje kože magnetni nanodelci tanke plasti kožni rak metakrilati true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2024-07-04 09:43:56 2024-07-04 10:08:12 2024-07-05 04:13:28 0000-00-00 00:00:00 2022 0 0 Str. 1-26 Št. 4, št. članka 689 Letn. 14 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2022-02-07 2022-03-16 2022-03-22 615:620.3 102307075 10.3390/pharmaceutics14040689 1999-4923 Skok-2022-Novel_Methacrylate-Based_Multilayer.pdf Skok-2022-Novel_Methacrylate-Based_Multilayer.pdf 1 0A9AFFE3ABD12AE9D2A99A8322086892 22d95e06b6d8662393192bdc0b3316da074882cf5140c27dd4fe6b09a9796906 6268b60e-39dc-11ef-8f49-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=181112 https://doi.org/10.3390/pharmaceutics14040689 0 70adf6ed-39dc-11ef-8f49-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=181113 Medicinska fakulteta 0 0 0