20.500.12556/DKUM-89370 The efficacy of probiotics as antiviral agents for the treatment of rotavirus gastrointestinal infections in children an updated overview of literature Enteric viruses, including the rotavirus, norovirus, and adenoviruses, are the most common cause of acute gastroenteritis. The rotavirus disease is especially prevalent among children, and studies over the past decade have revealed complex interactions between rotaviruses and the gut microbiota. One way to treat and prevent dysbiosis is the use of probiotics as an antiviral agent. This review focuses on the latest scientific evidence on the antiviral properties of probiotics against rotavirus gastroenteric infections in children. A total of 19 studies exhibited a statistically significant antiviral effect of probiotics. The main probiotics that were effective were Saccharomyces cerevisiae var. boulardii, Lacticaseibacillus rhamnosus GG, and various multi-strain probiotics. The underlying mechanism of the probiotics against rotavirus gastroenteric infections in children included immune enhancement and modulation of intestinal microbiota leading to shortening of diarrhoea. However, several clinical studies also found no significant difference in the probiotic group compared to the placebo group even though well-known strains were used, thus showing the importance of correct dosage, duration of treatment, quality of probiotics and the possible influence of other factors, such as the production process of probiotics and the influence of immunisation on the effect of probiotics. Therefore, more robust, well-designed clinical studies addressing all factors are warranted. probiotics microbiota rotaviruses probiotiki mikrobiota rotavirusi true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2024-07-05 09:14:00 2024-07-05 09:28:17 2024-07-06 04:02:48 0000-00-00 00:00:00 2022 0 0 Str. 1-21 Št. 12, št. člnka 2392 Letn. 10 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2022-10-27 2022-11-29 2022-12-02 613.292:616.3 135120643 10.3390/microorganisms10122392 2076-2607 Steyer-2022-The_Efficacy_of_Probiotics_as_Anti.pdf Steyer-2022-The_Efficacy_of_Probiotics_as_Anti.pdf 1 1B7A80CC6831F412178D5908245F520B 1dbf052288b8e92225316f06dcdd43ca0ebe7a5fd641773294959f3b3f0c8749 e199556d-3a9f-11ef-bcfd-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=181168 https://doi.org/10.3390/microorganisms10122392 0 2d6225eb-3a9e-11ef-bcfd-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=181167 Medicinska fakulteta 0 0 0