20.500.12556/DKUM-89543 The role of methylation of host and/or human papillomavirus (HPV) DNA in management of cervical intraepithelial neoplasia grade 2 (CIN2) lesions Cervical intraepithelial neoplasia grade 2 (CIN2) is an intermediate stage between CIN 1, which is a low-grade lesion, and CIN3, which is the immediate precursor of cervical cancer (CC). Traditionally, CIN2 was regarded as a high-grade lesion and was treated with conization or ablative methods. In recent years, there has been a shift in the management of younger patients, who are now more often being managed conservatively due to frequent spontaneous CIN2 regression and possible adverse effects of treatment on future pregnancies. Because the risk of progression to CC still exists with conservative management, a personalized approach is needed to identify patients with a higher probability of progression. In this regard, research has focused on the role of host and human papillomavirus (HPV) gene methylation. This systematic review summarizes the current knowledge regarding conservative CIN2 management focusing on the main methylation markers and its implementation in conservative CIN2 management, and it describes major ongoing longitudinal studies on the subject. The review showed that DNA methylation is an accurate predictor of disease progression and a valid triage tool for HPV-positive women, with CIN2 performing better than triage cytology. Because virtually all CCs are methylation-positive, methylation-negative women at baseline have an extremely low risk of CC. cervical intraepithelial lesion human papillomavirus gene methylation intraepitelijska lezija materničnega vratu človeški papiloma virus metilacija genov true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2024-07-19 08:33:02 2024-07-19 08:47:25 2024-07-20 04:06:54 0000-00-00 00:00:00 2023 0 0 Str. 1-15 Št. 7, št. članka 6479 Letn. 24 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-03-07 2023-03-28 2023-03-30 618.1 147516675 10.3390/ ijms24076479 1422-0067 Dovnik-2023-The_Role_of_Methylation_of_Host_an.pdf Dovnik-2023-The_Role_of_Methylation_of_Host_an.pdf 1 D777FB9E07172E6F5C5BF12E8A615B75 41fcab1c0f43cde9e6e474b966788ec856d1d3cea62a0b3cab33839f15f6a58c 87d22f1d-459a-11ef-8d11-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=181630 https://doi.org/10.3390/ijms24076479 1 c2df8113-4598-11ef-8d11-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=181628 Medicinska fakulteta 0 0 0