20.500.12556/DKUM-89754 Acute kidney injury after open-heart surgery procedures Akutno bubrežno oštećenje nakon operacija na otvorenom srcu Cardiac surgery-associated acute kidney injury (CS-AKI) is a major complication associated with increased morbidity and mortality. There are multiple diagnostic criteria for CS-AKI. Despite many new investigations available for improved AKI diagnostics, creatinine and urea remain the cornerstone of diagnostics in everyday clinical practice. There are three major pathophysiological mechanisms that contribute to kidney injury, i.e. renal hypoperfusion, inflammation with oxidative stress, and use of nephrotoxic agents. Some risk factors have been identified that can be modified during the course of treatment (use of nephrotoxic agents, duration of cardiopulmonary bypass, type of extracorporeal circulation, postoperative low cardiac output or hypotension). The aim of AKI prevention should always be to prevent aggravation of renal failure and, if possible, to avoid progression to renal replacement therapy, which in turn brings worse long-term outcomes. Akutno bubrežno oštećenje povezano s kardiokirurgijom (cardiac surgery-associated acute kidney injury, CS-AKI) je zna- čajna komplikacija s visokim pobolom i smrtnošću. Postoji više dijagnostičkih kriterija za dijagnozu CS-AKI. Usprkos mnogim novim istraživanjima, kreatinin i ureja ostaju temelj dijagnostike. Glavni patofiziološki procesi koji doprinose bubrežnom oštećenju su bubrežna hipoperfuzija, upala uzrokovana oksidativnim stresom i bubrežno oštećenje uzrokovano upotrebom nefrotoksičnih sredstava. Tijekom terapije može se utjecati na nekoliko čimbenika rizika (upotreba nefrotoksič- nih sredstava, trajanje kardiopulmonarne premosnice, tip izvantjelesne cirkulacije, smanjeni minutni volumen ili poslijeoperacijska hipotenzija). Cilj prevencije AKI je spriječiti progresiju bubrežnog oštećenja koje zahtijeva kompleksniju terapiju i donosi lošije dugoročne ishode. kidney injuries cardiac surgery perfusion oxidative stress dialysis bubrežno oštećenje kardiokirurgija perfuzija oksidativni stres dijaliza true false true Sestre milosrdnice University Hospital, Institute for Clinical Medical Research Angleški jezik Hrvaški jezik Znanstveno delo 2024-08-09 14:20:36 2024-08-09 14:43:17 2024-08-10 03:47:47 0000-00-00 00:00:00 2021 0 0 Ključne besede v slovenščini: poškodbe ledvic, srčna kirurgija, perfuzija, oksidativni stres, dializa Str. 120-126 Št. 1 Letn. 60 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2021-03-01 616.12-089 70352387 10.20471/acc.2021.60.01.17 1333-9451 Djordjevic-2021-ACUTE_KIDNEY_INJURY_AFTER_OPEN.pdf Djordjevic-2021-ACUTE_KIDNEY_INJURY_AFTER_OPEN.pdf 1 85DCE64E8D2D28712556E754A77AF77F 26322a81a34a7a5517539fc5dbe7dbface38baa6330f16e71971888224124da1 6b1748d2-564c-11ef-97b6-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=182194 https://doi.org/10.20471/acc.2021.60.01.17 0 d134616c-5649-11ef-97b6-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=182192 Medicinska fakulteta 0 0 0