20.500.12556/DKUM-89863 Impact of short-term topical steroid therapy on selective laser trabeculoplasty efficacy Background: To evaluate whether short-term use of topical steroid therapy affected the efficacy of selective laser trabeculoplasty (SLT) for primary open-glaucoma (POAG). Methods: 25 eyes of 25 patients, who used a drop of dexamethasone 0.1% 4 times a day for 7 days as post-laser therapy, formed the Steroid SLT group and 24 eyes of 24 patients, where no topical steroids or nonsteroidal anti-inflammatory agents as post-laser therapy were used, formed the No-steroid SLT group. Success was defined as an intraocular pressure (IOP) lowering exceeding 20% of pretreatment IOP. Results: The mean follow-up time was 21.24 months for the Steroid SLT group and 20.25 months for the No-steroid SLT group (p = 0.990). No significant difference was found between the two groups for mean pretreatment IOP (22.20 mmHg vs. 22.33 mmHg), and for mean IOP reductions during whole follow-up period. At all follow-up visits, the mean IOP reductions were smaller in the Steroid SLT group than in the No-steroid SLT group. At all follow-up visits, the mean percent IOP reduction was smaller in the Steroid SLT group than in the No-steroid SLT group, and such a difference was significant at 12 months (25.4% vs. 29.6%, p = 0.047) and 24 months (25.3% vs. 29.7%, p = 0.024). According to the Kaplan–Meier survival analysis, the 24-month success rate was 84% in the Steroid SLT group and 79.2% in the No-steroid SLT group, with no differences between the groups (p = 0.675). Conclusion: Short-term use of topical steroid therapy had no impact on the efficacy of SLT for POAG. selective laser trabeculoplasty topical steroid therapy primary open-angle glaucoma intraocular pressure selektivna laserska trabekuloplastika lokalna steroidna terapija primarni glavkom odprtega kota intraokularni tlak true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2024-08-14 15:24:57 2024-08-14 15:36:01 2024-08-15 03:53:27 0000-00-00 00:00:00 2021 0 0 Str. 1-10 Št. 18, št. članka 4249 Letn. 10 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2021-08-24 2021-09-16 2021-09-19 617.7 82697219 10.3390/jcm10184249 2077-0383 Gracner-2021-Impact_of_Short-Term_Topical_Ster.pdf Gracner-2021-Impact_of_Short-Term_Topical_Ster.pdf 1 79424A9A516BE4A8749904D34447A4DB 2b1353255be95850c1ad9541faa66311468e0a0e197652fb87e6d3ac31fcb245 d2761af5-5a41-11ef-990d-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=182443 https://doi.org/10.3390/jcm10184249 1 9ce5dd99-5a40-11ef-990d-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=182441 Medicinska fakulteta 0 0 0