20.500.12556/DKUM-89966 Multifunctional iron oxide nanoparticles as promising magnetic biomaterials in drug elivery a review A wide range of applications using functionalized magnetic nanoparticles (MNPs) in biomedical applications, such as in biomedicine as well as in biotechnology, have been extensively expanding over the last years. Their potential is tremendous in delivery and targeting systems due to their advantages in biosubstance binding. By applying magnetic materials-based biomaterials to different organic polymers, highly advanced multifunctional bio-composites with high specificity, efficiency, and optimal bioavailability are designed and implemented in various bio-applications. In modern drug delivery, the importance of a successful therapy depends on the proper targeting of loaded bioactive components to specific sites in the body. MNPs are nanocarrier-based systems that are magnetically guided to specific regions using an external magnetic field. Therefore, MNPs are an excellent tool for different biomedical applications, in the form of imaging agents, sensors, drug delivery targets/vehicles, and diagnostic tools in managing disease therapy. A great contribution was made to improve engineering skills in surgical diagnosis, therapy, and treatment, while the advantages and applicability of MNPs have opened up a large scope of studies. This review highlights MNPs and their synthesis strategies, followed by surface functionalization techniques, which makes them promising magnetic biomaterials in biomedicine, with special emphasis on drug delivery. Mechanism of the delivery system with key factors affecting the drug delivery efficiency using MNPs are discussed, considering their toxicity and limitations as well. multifunctional biomaterials bio-composites nanocarriers magnetic nanoparticles modification drug delivery biomateriali bio-kompoziti nanomateriali dostava zdravil interakcija true false true MDPI Angleški jezik Slovenski jezik https://www.mdpi.com/journal/jfb © 2024 by the authors Članek v reviji 2024-08-20 10:02:18 2024-08-20 10:02:18 2026-01-31 03:16:01 0000-00-00 00:00:00 2024 0 0 34 str. iss. 8, [article no.] 227 Vol. 15 14 Aug. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-07-16 2024-08-12 2024-08-14 620.3 204640003 10.3390/jfb15080227 2079-4983 jfb-15-00227.pdf jfb-15-00227.pdf 1 F9AEA0DA85C26D7932968451ACDC42E7 1fdaedc83d13bc655af72ebe4a4779c8192a689f3a32b48388bbc5eddf77e056 74440532-fdd1-11f0-8805-00155d00018d https://dk.um.si/Dokument.php?lang=slv&id=202865 https://www.mdpi.com/2079-4983/15/8/227 0 8082f5a7-fdd1-11f0-8805-00155d00018d https://dk.um.si/Dokument.php?lang=slv&id=202866 Fakulteta za kemijo in kemijsko tehnologijo Medicinska fakulteta 0 0 0