20.500.12556/DKUM-90119 Optimizacija proizvodnje magnetnih nanodelcev oblečenih s citronsko kislino na mikroreaktorskem sistemu diplomsko delo visokošolskega strokovnega študijskega programa I. stopnje Optimization of the production of magnetic nanoparticles coated with citric acid in a microreactor system V sklopu diplomskega dela smo sintetizirali magnetne nanodelce (magnetit/maghemit) z uporabo večih modulov na mikroreaktoskem sistemu. Namen diplomskega dela je bil raziskati, kolikšna je optimalna količina citronske kisline, ki jo dodamo sintetiziranim nanodelcem, da so le-ti najbolje prevlečeni in pripravljeni za uporabo v različnih biomedicinskih aplikacijah. Sintezo nanodelcev smo začeli s pripravo raztopin, katere smo kasneje uporabili na mikroreaktorju. Sinetizirali smo 1 vozrec nanodelcev brez dodatka citronske kisline in 11 različnih vzorcev z isto množino nanodelcev železovega oksida ter različno množino dodane citronske kisline. Vzroce smo nato analizirali z metodo DLS in ugotovili, v katerih primerih je bilo oblačenje uspešno. Merili smo zeta potencial in velikost delcev v odvisnosti od pH. Rezultati kažejo, da je za uspešno sintezo nanodelcev potrebna izoelektrična točka pri pH 6,8. Ugotovili smo, da je bilo oblačenje nanodelcev uspešno pri vzorcih, pri katerih se izoelektrična točka nahaja med pH 2 in 3. As part of this thesis, we synthesized magnetic nanoparticles (magnetite/maghemite) using several modules on a microreactor system. The aim of the thesis was to investigate the optimal amount of citric acid to add to the synthesized nanoparticles so that they are best coated and prepared for use in various biomedical applications. We started the synthesis of nanoparticles by preparing solutions, which were later used in the microreactor. We synthesized 1 set of nanoparticles without the addition of citric acid and 11 different samples with the same amount of iron oxide nanoparticles and a different amount of added citric acid. We then analyzed the causes using the DLS method and found out in which cases the dressing was successful. We measured the potential in particle size as a function of pH. The results show that an isoelectric point at pH 6.8 is required for successful synthesis of nanoparticles. We found that nanoparticle coating was successful for samples with an isoelectric point between pH 2 and 3. magnetni nanodelci Fe3O4 citronska kislina optimizacija mikroreaktorski sistem magnetic nanoparticles Fe3O4 citric acid optimization microreactor system true true false [L. Tement] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2024-08-22 19:47:26 2024-09-16 14:40:09 2024-12-21 03:12:52 0000-00-00 00:00:00 2024 0 Maribor 0 Maribor 1 spletni vir (1 datoteka PDF (IX, 26 f.)) 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 66.011(043.2) 220055299 VS_Tement_Lucija_2024.pdf VS_Tement_Lucija_2024.pdf 1 DF8EF7F886B5AFE7C97488BBC07FF349 3160d2afd7c4e7b307a897daf1a5b0c1fc4f841b5f9d1e8361feda72340ef9b9 0e9ba12b-71cc-11ef-909e-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=185122 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0