20.500.12556/DKUM-90159 Reinforcing ethyl cellulose aerogels with poly(lactic acid) for enhanced bone regeneration Developing double porous biodegradable and biocompatible scafolds that can incorporate and release drugs in a controlled manner holds immense potential in regenerative medicine. This study presents a synthesis method for preparing a macro-mesoporous scafold, where poly(lactic acid) adds to the macroporous region and mechanical properties, and ethyl cellulose adds to the surface area (182 m2 /g). High surface area enables the incorporation of model drug indomethacin with an entrapment efciency of 17.0% and its later controlled release profle. The resulting scafold has desirable mechanical properties in the range of a natural trabecular bone with a compressive modulus of 22.4 MPa. The material is stable in the simulated body fuids for 120 days before the slow degradation starts. In vitro studies demonstrate the material’s ability to support bone cell adhesion, proliferation, and diferentiation, promoting osteogenic activity. Overall, the unique combination of poly(lactic acid) and ethyl cellulose produces advanced materials with tailored macro and mesopore properties, remarkable mechanical properties, optimal degradation rate, and drug delivery potential, making it a promising candidate for bone scafolds in regenerative medicine and tissue engineering bio composite polymer-matrix composites (PMCs) polymers porosity/voids secondary ion mass spectrometry polimeri poroznost spektrometrija true false true Kluwer (Springer Link) Angleški jezik Slovenski jezik https://link.springer.com/journal/10570 © The Author(s) 2024 Članek v reviji 2024-08-23 12:28:38 2024-08-23 12:28:41 2026-01-14 03:14:42 0000-00-00 00:00:00 2024 0 0 19 str. Published online: 13 April 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-10-16 2024-04-08 2024-04-13 66.02 192685315 10.1007/s10570-024-05905-w 1572-882X s10570-024-05905-w.pdf s10570-024-05905-w.pdf 1 9B10AB0B9E8CFAEA516EA948134F453A 59799cfeec2fdd8cf7c055cf780066718982a82b14be2976096a922c4c910a85 a3653909-f04f-11f0-823a-00155d580e02 https://dk.um.si/Dokument.php?lang=slv&id=201930 https://link.springer.com/article/10.1007/s10570-024-05905-w 0 b2236739-f04f-11f0-823a-00155d580e02 https://dk.um.si/Dokument.php?lang=slv&id=201931 Fakulteta za kemijo in kemijsko tehnologijo Medicinska fakulteta 0 0 0