20.500.12556/DKUM-90527 Vpliv probiotikov na potek crohnove bolezni The effect of probiotics on the course of crohn´s disease Crohnova bolezen je vnetna črevesna bolezen in se kaže kot kronično vnetje v različnih delih prebavil, pojavnost bolezni pa v zadnjih letih narašča. Potek bolezni je progresiven, ne samo s črevesnimi spremembami, temveč tudi z zunajčrevesnimi sistemskimi manifestacijami, ki resno vplivajo na kakovost življenja in prognozo bolnikov Dokončnega zdravila za Crohnovo bolezen še ni, vendar obstajajo načini za lajšanje simptomov. Probiotiki so definirani kot živi mikroorganizmi, ki pozitivno delujejo na zdravje gostitelja, kadar jih apliciramo v ustreznih okoliščinah. Imajo pomembno vlogo pri vzdrževanju imunološkega ravnovesja v prebavnem traktu z neposredno interakcijo z imunskimi celicami. Učinkovitost probiotika je lahko odvisna od vrste, odmerka in bolezni, trajanje terapije pa je odvisno od klinične indikacije. Nekatere raziskave so pokazale, da je dodajanje probiotikov po operaciji koristno pri bolnikih s Crohnovo boleznijo, četudi druge študije kažejo, da zdravljenje z več sevi probiotikov ni bistveno spremenilo vnetja črevesja. Probiotiki vplivajo na črevesno mikrobioto blagodejno, zmanjšujejo vnetje in da je njihovo delovanje sevno-specifično. Pa vendar njihovega vpliva na potek Crohnove bolezni ne moremo natančno opredeliti, zato je potrebno na to temo opraviti več raziskav. Crohn's disease is an inflammatory bowel disease that manifests as chronic inflammation in various parts of the digestive tract, with the incidence of the disease increasing in recent years. The progression of the disease is not only associated with intestinal changes but also with extraintestinal systemic manifestations, which seriously affect the quality of life and prognosis of patients. There is no definitive cure for Crohn's disease yet, but there are ways to alleviate the symptoms. Probiotics are defined as live microorganisms that have a positive effect on the host's health when applied under appropriate conditions. They play an important role in maintaining immunological balance in the digestive tract through direct interaction with immune cells. The effectiveness of probiotics may depend on the type, dose, and disease, and the duration of therapy depends on the clinical indication. Some studies have shown that adding probiotics after surgery is beneficial for patients with Crohn's disease, although other studies suggest that treatment with multiple strains of probiotics did not significantly change intestinal inflammation. Probiotics have a beneficial effect on the gut microbiota, reducing inflammation, and their action is strain-specific. However, their impact on the course of Crohn's disease cannot be precisely defined, so more research is needed on this topic. Crohnova bolezen probiotiki Crohn's disease probiotics true true false [M. Trobentar] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2024-09-06 17:46:24 2024-12-24 09:32:32 2025-02-18 14:34:36 0000-00-00 00:00:00 2024 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.344-002:613.292(043.2) 215561987 VS_Trobentar_Melisa_2024.pdf VS_Trobentar_Melisa_2024.pdf 1 2625E1D9F0D1216792B450F2F52FC50F c13574cefcde1b5a4843c2a0dcd2cb499633c9ce7cba1c35e83eed75776edce9 1f527c5c-c1d1-11ef-8836-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=187564 Fakulteta za zdravstvene vede 0 0 0