20.500.12556/DKUM-90600 Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response Polyester biomaterials play a crucial in vascular surgery, but suffer from unspecific protein adsorption, thrombogenicity, and inadequate endothelial cell response, which limit their success. To address these issues, we investigated the functionalization of polyester biomaterials with antithrombogenic polysaccharide coatings. A two-step and water-based method was used to coat cationized polycaprolactone with different sulfated polysaccharides (SPS), which resulted in long-term stability, tunable morphology, roughness, film thickness, chemical compositions, zeta potential, and water content. The coatings significantly increased the anticoagulant activity and reduced the thrombogenicity of polycaprolactone, particularly with highly sulfated heparin and cellulose sulfate. Less SPS, such as chondroitin sulfate, fucoidan, and carrageenan, despite showing reduced anticoagulant activity, also exhibited lower fibrinogen adsorption. The adhesion and viability of human primary endothelial cells cultured on modified polycaprolactone correlated with the type and sulfate content of the coatings. polyester biomaterials vascular surgery antithrombogenic polysaccharide coatings poliestrski biomateriali vaskularna kirurgija antitrombogene polisaharidne prevleke true false true Elsevier Angleški jezik Slovenski jezik https://www.sciencedirect.com/journal/iscience © 2024 The Author(s). Published by Elsevier Inc. Članek v reviji 2024-09-10 14:32:38 2024-09-10 14:32:39 2026-02-13 12:26:21 0000-00-00 00:00:00 2024 0 0 20 str. iss. 9, [article no.] 110692 Vol. 27 September 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-03-25 2024-08-05 2024-09-02 577.114.4:60 206885891 10.1016/j.isci.2024.110692 2589-0042 1-s2.0-S2589004224019175-main.pdf 1-s2.0-S2589004224019175-main.pdf 1 202050ACAC933F80647C78442593E186 51a95d1946a2cfc7ce4379ef5bf5ffc3a65ed8ca18ad5756f56c8e5f9b95d07c 5bae8144-6f72-11ef-b637-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=184835 https://www.sciencedirect.com/science/article/pii/S2589004224019175?via%3Dihub 0 6d600ddf-6f72-11ef-b637-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=184836 Fakulteta za strojništvo Fakulteta za elektrotehniko, računalništvo in informatiko 0 0 0