20.500.12556/DKUM-90983 The role of environmental PM2.5 in admission acute heart failure in ST-elevation myocardial infarction patients an observational retrospective study Background: Air pollution with increased concentrations of fine (< 2.5 μm) particulate matter (PM2.5) increases the risk of cardiovascular morbidity and mortality. Even short-term increase of PM2.5 may help trigger ST-elevation myocardial infarction (STEMI) and heart failure (HF) in susceptible individuals, even in areas with good air quality. Purpose: To evaluate the role of PM2.5 levels ≥ 20 μg/m3 in admission acute HF in STEMI patients. Materials and Methods: In 290 STEMI patients with the leading reperfusion strategy primary percutaneous coronary intervention (PPCI), we retrospectively studied independent predictors of admission acute HF and included admission demographic and clinical data as well as ambient PM2.5 levels ≥ 20 μg/m3. We defined admission acute HF in STEMI patients as classes II–IV by Killip Kimball classification. Results: Acute admission HF was observed in 34.5% of STEMI patients. PPCI was performed in 87.1% of acute admission HF patients and in 94.7% non-HF patients (p= 0.037). Significant independent predictors of acute admission HF were prior diabetes (OR 2.440, 95% CI 1.100 to 5.400, p=0.028), admission LBBB (OR 10.190, 95% CI 1.160 to 89.360, p=0.036), prior resuscitation (OR 2.530, 95% CI 1.010 to 6.340, p=0.048), admission troponin I≥ 5μg/l (OR 3.390, 95% CI 1.740 to 6.620, p< 0.001), admission eGFR levels (0.61, 95% CI 0.52 to 0.72, p < 0.001), and levels of PM2.5 ≥ 20 μg/m3 (OR 2.140, 95% CI 1.005 to 4.560, p=0.049) one day before admission. Conclusion: Temporary short-term increase in PM2.5 levels (≥ 20 μg/m3) one day prior to admission in an area with mainly good air quality was among significant independent predictors of acute admission HF in STEMI patients. admission acute heart failure ST-elevation myocardial infarction air pollution PM2.5 akutno srčno popuščanje miokardni infarkt z dvigom ST (STEMI) onesnaženost zraka true false true Dove Medical Press Angleški jezik Slovenski jezik Znanstveno delo 2024-10-14 14:00:10 2024-10-14 14:16:44 2024-10-15 03:10:59 0000-00-00 00:00:00 2021 0 0 Str. 8473-8479 Letn. 14 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2021-09-23 2021-10-29 2021-11-18 616.127-005.8 87618563 10.2147/IJGM.S340301 1178-7074 Sinkovic-2021-The_Role_of_Environmental_PM_sub.pdf Sinkovic-2021-The_Role_of_Environmental_PM_sub.pdf 1 50E2E2BB8FB0CD3D531184E752AF67D0 438a29e58f64f98fbabbe6a659176eca141f91ab14eef9d2d6df3c0ffc4acd7d f4e861ae-8a25-11ef-a9b1-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=186482 https://doi.org/10.2147/IJGM.S340301 1 df83e856-8a23-11ef-a9b1-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=186480 Medicinska fakulteta 0 0 0