20.500.12556/DKUM-90998 The role of cAMP in beta cell stimulus-secretion and intercellular coupling Pancreatic beta cells secrete insulin in response to stimulation with glucose and other nutrients, and impaired insulin secretion plays a central role in development of diabetes mellitus. Pharmacological management of diabetes includes various antidiabetic drugs, including incretins. The incretin hormones, glucagon-like peptide-1 and gastric inhibitory polypeptide, potentiate glucose-stimulated insulin secretion by binding to G protein-coupled receptors, resulting in stimulation of adenylate cyclase and production of the secondary messenger cAMP, which exerts its intracellular effects through activation of protein kinase A or the guanine nucleotide exchange protein 2A. The molecular mechanisms behind these two downstream signaling arms are still not fully elucidated and involve many steps in the stimulus-secretion coupling cascade, ranging from the proximal regulation of ion channel activity to the central Ca2+ signal and the most distal exocytosis. In addition to modifying intracellular coupling, the effect of cAMP on insulin secretion could also be at least partly explained by the impact on intercellular coupling. In this review, we systematically describe the possible roles of cAMP at these intra- and inter-cellular signaling nodes, keeping in mind the relevance for the whole organism and translation to humans. cAMP beta cells stimulus-secretion coupling intercellular coupling PKA Epac2A beta celice povezave med dražljaji in izločanjem medcelične povezave true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2024-10-16 14:55:28 2024-10-16 15:06:04 2024-10-17 03:10:10 0000-00-00 00:00:00 2021 0 0 Str. 1-26 št. 7, št. članka 1658 Letn. 10 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2021-05-05 2021-06-28 2021-07-01 612.349.7 70397955 10.3390/cells10071658 2073-4409 Stozer-2021-The_Role_of_cAMP_in_Beta_Cell_Stim.pdf Stozer-2021-The_Role_of_cAMP_in_Beta_Cell_Stim.pdf 1 5F48968EF753EFF848CD5ABB13AC3B49 abd6a3e7b155239445005240856c3d755477ddf27c9daf6679878eff352f0f5d 371e3ec5-8bbf-11ef-a0d7-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=186539 https://doi.org/10.3390/cells10071658 0 ebc52f4b-8bbd-11ef-a0d7-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=186538 Medicinska fakulteta Fakulteta za naravoslovje in matematiko 0 0 0