20.500.12556/DKUM-91070 Translational regulation in hepatocellular carcinogenesis The mortality of hepatocellular carcinoma (HCC) is distributed unevenly worldwide. One of the major causes is hepatitis B or hepatitis C virus infection and the development and progression of liver cirrhosis. The carcinogenesis of HCC is among others regulated via the mTOR (mechanistic target of rapamycin) signaling pathway and represents a possible method of targeted treatment. The aim of our article was to address the most recent clinical advances and findings of basic studies on the mTOR signaling pathway and the involved factors. Risk factors play a key role in dysregulation of the signaling pathway, where both mTORCs are upregulated and protein synthesis is altered. eIFs and, to a lesser extent, eEFs play an essential role in this process. Whether the factor will be upregulated or downregulated, among others, depends on hepatitis B/C virus infection. The amount of a particular factor in a patient sample lets us know whether HCC recurrence will occur, what is the likelihood of chemoresistance, and what outcome is predicted for patients with an increased value. Our analysis shows that in addition to mTOR, eIF3, eIF4, and eIF5 play an important role, as they can serve as biomarkers for non- and virus-related HCC. mTOR virus related HCC non-virus related HCC cancer translation initiation liver Hepatocelularni karcinom rak povezava z virusom začetek prevajanja jetra true false true Dovepress Angleški jezik Slovenski jezik Znanstveno delo 2024-10-18 09:47:58 2024-10-18 10:14:25 2024-10-19 03:11:39 0000-00-00 00:00:00 2021 0 0 Str. 4359-4369 Letn. 15 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2021-05-03 2021-10-04 2021-10-14 616.36-006 83680515 10.2147/DDDT.S255582 1177-8881 Tomazic-2021-Translational_Regulation_in_Hepat.pdf Tomazic-2021-Translational_Regulation_in_Hepat.pdf 1 E55BEBA045618C20F661AE541769F393 6801f8e53df1595dd23f69afd60b1cc7b2f8ecd22aa4051676072694c12ea01d cbe00d76-8d28-11ef-a8b7-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=186647 https://doi.org/10.2147/DDDT.S255582 0 4ce3117c-8d25-11ef-a8b7-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=186645 Medicinska fakulteta 0 0 0