20.500.12556/DKUM-91086 Targeting cardiovascular risk factors through dietary adaptations and caloric restriction mimetics The average human life expectancy continues to rise globally and so does the prevalence and absolute burden of cardiovascular disease. Dietary restriction promotes longevity and improves various cardiovascular risk factors, including hypertension, obesity, diabetes mellitus, and metabolic syndrome. However, low adherence to caloric restriction renders this stringent dietary intervention challenging to adopt as a standard practice for cardiovascular disease prevention. Hence, alternative eating patterns and strategies that recapitulate the salutary benefits of caloric restriction are under intense investigation. Here, we first provide an overview of alternative interventions, including intermittent fasting, alternate-day fasting and the Mediterranean diet, along with their cardiometabolic effects in animal models and humans. We then present emerging pharmacological alternatives, including spermidine, NAD+ precursors, resveratrol, and metformin, as promising caloric restriction mimetics, and briefly touch on the mechanisms underpinning their cardiometabolic and health-promoting effects. We conclude that implementation of feasible dietary approaches holds the promise to attenuate the burden of cardiovascular disease and facilitate healthy aging in humans. autophagy caloric restriction caloric restriction mimetics cardiovascular risk factors dietary regimens hypertension intermittent fasting obesity avtofagija omejitev kalorij mimetiki omejevanja kalorij dejavniki tveganja za bolezni srca in ožilja dietni režimi hipertenzija prekinitveno stradanje debelost true false true Frontiers Angleški jezik Slovenski jezik Znanstveno delo 2024-10-21 09:40:55 2024-10-21 10:05:18 2024-10-22 03:10:28 0000-00-00 00:00:00 2021 0 0 Str. 1-17 št. članka 758058 Letn. 8 sept. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2021-08-13 2021-09-07 2021-09-30 616.1:613.2 130726403 10.3389/fnut.2021.758058 2296-861X Voglhuber-2021-Targeting_Cardiovascular_Risk_F.pdf Voglhuber-2021-Targeting_Cardiovascular_Risk_F.pdf 1 9F684E98AF83231205F79BBFD26D1E2B 0eb122cbefaeff824ba5dcb81ab004659c9e2546e0bd2a61e35788d9acd3bf80 f834f477-8f82-11ef-9bfc-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=186697 https://doi.org/10.3389/fnut.2021.758058 0 d06160ba-8f7f-11ef-9bfc-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=186696 Medicinska fakulteta 0 0 0