20.500.12556/DKUM-91147 A critical assessment of microbial-based antimicrobial sanitizing of inanimate surfaces in healthcare settings The global rise in antimicrobial resistance (AMR) poses a significant public health threat, especially in healthcare settings, where controlling the spread of antimicrobial genes is crucial. While person-to-person transmission remains the primary route for healthcare-associated infections (HAIs), hospital surfaces serve as key reservoirs for antimicrobial-resistant microorganisms. Regular cleaning and disinfection of these surfaces are essential. Microbial-based products for sanitizing hospital surfaces have emerged as promising tools to combat HAIs and AMR. However, a review of 32 publications found inconsistencies and potential risks. A total of 15 publications included hospital-based trials, while the rest were either in vitro or in situ assays, reviews, book chapters, or commentaries. In most of the hospital-based studies, specific strains of applied microorganisms were not identified, and the term “probiotic” was inaccurately used. These products mainly featured spores from Bacillus and Priestia genera, which was mainly hypothesized to work through competitive exclusion. Most hospital-based studies have shown that the application of microbial-based products resulted in a significant reduction in pathogens on surfaces, thereby contributing to a decrease in the incidence of healthcare-associated infections (HAIs). Further research is however needed to understand the effectiveness, mechanisms of action, and safety of microbial-based sanitizing agents. Strain-level identification is crucial for safety assessments, yet many reviewed products lacked this information. Consequently, there is a need for rigorous safety evaluations within existing regulatory frameworks to ensure the efficacy and safety of microbial-based cleaning products in healthcare settings. microbial cleaning hygiene Bacillus spores beneficial microbes genus Priestia mikrobno čiščenje higiena bacil spore koristni mikrobi rod Prestia true false true Frontiers Research Foundation Angleški jezik Slovenski jezik Znanstveno delo 2024-11-21 08:08:20 2024-11-21 08:08:20 2024-11-25 10:59:37 0000-00-00 00:00:00 2024 0 0 str. [1-17] št. članka 1412269 letn. 15 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-04-04 2024-05-22 2024-06-12 579.63:614.48 198643715 10.3389/fmicb.2024.1412269 1664-302X https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1412269/full 1 65a6321d-a7d7-11ef-9ebb-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=186870 Fakulteta za zdravstvene vede 0 0 0