20.500.12556/DKUM-91232 Changes in the extracellular matrix in endometrial and cervical cancer a systematic review Endometrial and cervical cancers are the two most common gynaecological malignancies and among the leading causes of death worldwide. The extracellular matrix (ECM) is an important component of the cellular microenvironment and plays an important role in developing and regulating normal tissues and homeostasis. The pathological dynamics of the ECM contribute to several different processes such as endometriosis, infertility, cancer, and metastasis. Identifying changes in components of ECM is crucial for understanding the mechanisms of cancer development and its progression. We performed a systematic analysis of publications on the topic of changes in the extracellular matrix in cervical and endometrial cancer. The findings of this systematic review show that matrix metalloproteinases (MMP) play an important role impacting tumour growth in both types of cancer. MMPs degrade various specific substrates (collagen, elastin, fibronectin, aggrecan, fibulin, laminin, tenascin, vitronectin, versican, nidogen) and play a crucial role in the basal membrane degradation and ECM components. Similar types of MMPs were found to be increased in both cancers, namely, MMP-1, MMP-2, MMP-9, and MMP-11. Elevated concentrations of MMP-2 and MMP-9 were correlated with the FIGO stage and are associated with poor prognosis in endometrial cancer, whereas in cervical cancer, elevated concentrations of MMP-9 have been associated with a better outcome. Elevated ADAMTS levels were found in cervical cancer tissues. Elevated disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) levels were also found in endometrial cancer, but their role is still unclear. Following these findings, this review reports on tissue inhibitors of ECM enzymes, MMPs, and ADAMTS. The present review demonstrates changes in the extracellular matrix in cervical and endometrial cancers and compared their effect on cancer development, progression, and patient prognosis. extracellular matrix endometrial cancer cervical cancer zunajcelični matriks endometrijski rak rak materničnega vratu true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2024-12-02 13:13:33 2024-12-02 13:31:56 2024-12-03 03:08:54 0000-00-00 00:00:00 2023 0 0 Str. 1-15 št 6, št. članka 5463 Letn. 24 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2022-12-27 2023-03-09 2023-03-13 618.1 145161731 10.3390/ijms24065463 1422-0067 Padeznik_2023_Changes_in_the_Extracellular_Matrix.pdf Padeznik_2023_Changes_in_the_Extracellular_Matrix.pdf 1 D93994B6EC6C2ECBAD44FF9A89AB4E4B 466358cfa1fbd84bc16016dc1fd17acd96d3a3780ec207b8e56c781141311e5d 4de355b6-b0a9-11ef-9fd9-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=187050 https://doi.org/10.3390/ijms24065463 1 da7f4d7a-b0a6-11ef-9fd9-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=187049 Medicinska fakulteta 0 0 0