20.500.12556/DKUM-91238 Review of potential drug-eluting contact lens technologies The field of ophthalmology is expanding exponentially, both in terms of diagnostic and therapeutic capabilities, as well as the worldwide increasing incidence of eye-related diseases. Due to an ageing population and climate change, the number of ophthalmic patients will continue to increase, overwhelming healthcare systems and likely leading to under-treatment of chronic eye diseases. Since drops are the mainstay of therapy, clinicians have long emphasised the unmet need for ocular drug delivery. Alternative methods, i.e., with better compliance, stability and longevity of drug delivery, would be preferred. Several approaches and materials are being studied and used to overcome these drawbacks. We believe that drug-loaded contact lenses are among the most promising and are a real step toward dropless ocular therapy, potentially leading to a transformation in clinical ophthalmic practice. In this review, we outline the current role of contact lenses in ocular drug delivery, focusing on materials, drug binding and preparation, concluding with a look at future developments. contact lens materials advanced ocular drug delivery dropless ocular therapy drug-laden contact lens materiali za kontaktne leče napredna očesna zdravila očesna terapija brez kapljic kontaktna leča z zdravilom true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2024-12-03 14:24:14 2024-12-03 14:39:52 2024-12-04 03:08:53 0000-00-00 00:00:00 2023 0 0 Str. 1-29 št. 10, št. članka 3653 Letn. 16 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-03-14 2023-05-09 2023-05-11 617.7 152158979 10.3390/ma16103653 1996-1944 Lovrec_2023_Review_of_Potential_Drug-Eluting.pdf Lovrec_2023_Review_of_Potential_Drug-Eluting.pdf 1 DA7D6CC61AEFCF687C052EF30AFCD456 ea2cd162511b009bc8797434a058c61e5ec469edf3eeaa14a6dbd4a6ae949b5b efdca04f-b17b-11ef-a045-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=187066 https://doi.org/10.3390/ma16103653 0 e4d8714c-b179-11ef-a045-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=187065 Medicinska fakulteta 0 0 0