20.500.12556/DKUM-91259 Meta-analytic comparison of global RNA transcriptomes of acute and chronic myeloid leukemia cells reveals novel gene candidates governing myeloid malignancies Despite advances in the understanding of genetic risk factors and molecular mechanisms underlying acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), clinical outcomes of current therapies in terms of disease relapse and mortality rate pose a great economic and social burden. To overcome this, the identification of new molecular prognostic biomarkers and pharmacological targets is crucial. Recent studies have suggested that AML and CML may share common pathogenic mechanisms and cellular substrates. To this end, in the present study, global transcriptome profiles of AML and CML at the molecular and cellular level were directly compared using a combination of meta-analysis and modern statistics, and novel candidate genes and specific biological processes associated with the pathogenesis of AML and CML were characterized. Our study significantly improves our current understanding of myeloid leukemia and will help develop new therapeutic targets and biomarkers for disease progression, management and treatment response. AML CML meta-analysis lincRNA spliceosome Akutna mieloblastna levkemija metaanaliza lincRNA spliceosom true false true MDPI Angleški jezik Slovenski jezik https://www.mdpi.com/journal/cancers © 2022 by the authors Znanstveno delo 2024-12-05 09:20:52 2024-12-05 09:40:21 2025-04-10 08:56:34 0000-00-00 00:00:00 2022 0 0 Str. 1-16 št. 19, št. članka 4681 Letn. 14 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2022-09-02 2022-09-22 2022-09-26 616.155.392 123193347 10.3390/cancers14194681 2072-6694 Jurgec_2022_Meta-Analytic_Comparison.pdf Jurgec_2022_Meta-Analytic_Comparison.pdf 1 BCFA9C4523D697EFD5CBB44F36CBF592 06fdf22952d3593e5c4b943d8a061d0bb1e0589317c5afbb6155d1151859760d 62ce32aa-b2e4-11ef-9aff-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=187107 https://doi.org/10.3390/cancers14194681 1 d8748717-b2e1-11ef-9aff-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=187104 Medicinska fakulteta Fakulteta za kemijo in kemijsko tehnologijo 0 0 0