20.500.12556/DKUM-91327 Initiation and elongation factor co-expression correlates with recurrence and survival in epithelial ovarian cancer High grade epithelial ovarian cancer (EOC) represents a diagnostic and therapeutic challenge due to its aggressive features and short recurrence free survival (RFS) after primary treatment. Novel targets to inform our understanding of the EOC carcinogenesis in the translational machinery can provide us with independent prognostic markers and provide drugable targets. We have identified candidate eukaryotic initiation factors (eIF) and eukaryotic elongation factors (eEF) in the translational machinery for differential expression in EOC through in-silico analysis. We present the analysis of 150 ovarian tissue microarray (TMA) samples on the expression of the translational markers eIF2α, eIF2G, eIF5 (eIF5A and eIF5B), eIF6 and eEF1A1. All translational markers were differentially expressed among non-neoplastic ovarian samples and tumour samples (borderline tumours and EOC). In EOC, expression of eIF5A was found to be significantly correlated with recurrence free survival (RFS) and expression of eIF2G and eEF1A1 with overall survival (OS). Expression correlation among factor subunits showed that the correlation of eEF1A1, eIF2G, EIF2α and eIF5A were significantly interconnected. eIF5A was also correlated with eIF5B and eIF6. Our study demonstrates that EOCs have different translational profile compared to benign ovarian tissue and that eIF5A is a central dysregulated factor of the translation machinery. epithelial ovarian cancer initiation and elongation factor translational markers epitelijski rak jajčnikov iniciacijski in podaljševalni dejavniki translacijski označevalci true false true BioMed Central Angleški jezik Slovenski jezik Znanstveno delo 2024-12-12 14:50:04 2024-12-12 15:10:29 2024-12-13 03:10:22 0000-00-00 00:00:00 2022 0 0 Str. 1-11 št. članka 73 Letn. 15 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2021-10-07 2022-05-10 2022-06-19 618.177-089.888.11 112645635 10.1186/s13048-022-00998-y 1757-2215 Sobocan_2022_Initiation_and_elongation_factor.pdf Sobocan_2022_Initiation_and_elongation_factor.pdf 1 78081C355D9C34BD594508192DD2F172 022bb2c0da2a25373147d2946e02e4ecff113c65bf690536a2a4320cc25fd58d bab1f2dd-b892-11ef-b21d-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=187301 https://doi.org/10.1186/s13048-022-00998-y 1 ff5de4ef-b88f-11ef-b21d-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=187299 Medicinska fakulteta 0 0 0