20.500.12556/DKUM-91501 Optimization of the supercritical extraction and decarboxylation process of industrial hemp Cannabinoids are the main active ingredients of Cannabis sativa L., obtained by a suitable extraction method and decarboxylation, in which the acid forms of the cannabinoids are converted into active forms. Supercritical CO2 extraction method and decarboxylation process were optimized for 7 cannabinoids (CBD, CBDA, THC, THCA, CBGA, CBN and CBC). The optimal extraction conditions for all cannabinoids were determined at a temperature of 60 °C and a pressure of 300 bar to 550 bar. At higher temperatures and reaction times, a significant depletion of neutral cannabinoids was observed. The optimal conditions of the decarboxylation process varied depending on the component. For the CBD component, which could be measured in the highest concentrations (560 mg/g), the optimal conditions were 140 °C and 10 min. The study can be an important model for predicting the behavior of cannabinoids under certain parameters. supercritical fluids extraction cannabinoids decarboxilation Cannabis sativa I superkritične tekočine kanabinoidi dekarboksilacija true false true Elsevier Angleški jezik Slovenski jezik https://www.sciencedirect.com/journal/journal-of-co2-utilization © 2024 The Author(s) Članek v reviji 2025-01-08 14:54:34 2025-01-08 14:54:34 2026-01-19 14:54:52 0000-00-00 00:00:00 2025 0 0 13 str. Vol. 91, [article no.] 103007 Jan. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-06-28 2024-12-16 2024-12-21 66.02 221113603 10.1016/j.jcou.2024.103007 2212-9839 1-s2.0-S2212982024003421-main.pdf 1-s2.0-S2212982024003421-main.pdf 1 78A177C8CB3AB4CBECE13A60B41EBCC5 89f9d80d20e534ddf3a6760799d5848a78f2e19f6a7317b8e1f785d745597783 c07fd814-cdc8-11ef-9362-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=187699 https://www.sciencedirect.com/science/article/pii/S2212982024003421?via%3Dihub 0 6b4a299e-f53e-11f0-94a4-00155d580e02 https://dk.um.si/Dokument.php?lang=slv&id=202180 Fakulteta za kemijo in kemijsko tehnologijo Medicinska fakulteta 0 0 0