20.500.12556/DKUM-91683 Why? - Successful Pseudomonas aeruginosa clones with a focus on clone C The environmental species Pseudomonas aeruginosa thrives in a variety of habitats. Within the epidemic population structure of P. aeruginosa, occassionally highly successful clones that are equally capable to succeed in the environment and the human host arise. Framed by a highly conserved core genome, individual members of successful clones are characterized by a high variability in their accessory genome. The abundance of successful clones might be funded in specific features of the core genome or, although not mutually exclusive, in the variability of the accessory genome. In clone C, one of the most predominant clones, the plasmid pKLC102 and the PACGI-1 genomic island are two ubiquitous accessory genetic elements. The conserved transmissible locus of protein quality control (TLPQC) at the border of PACGI-1 is a unique horizontally transferred compository element, which codes predominantly for stress-related cargo gene products such as involved in protein homeostasis. As a hallmark, most TLPQC xenologues possess a core genome equivalent. With elevated temperature tolerance as a characteristic of clone C strains, the unique P. aeruginosa and clone C specific disaggregase ClpG is a major contributor to tolerance. As other successful clones, such as PA14, do not encode the TLPQC locus, ubiquitous denominators of success, if existing, need to be identified. disaggregase FtsH genomic island protein homeostasis pulsed field gel electrophoresis whole genome sequencing dezagregacija genomski otok proteinska homeostaza elektroforeza v pulznem polju sekvenciranje celotnega genoma true false true Blackwell Publishing Angleški jezik Slovenski jezik Znanstveno delo 2025-01-28 09:10:34 2025-01-28 09:46:03 2025-01-29 03:12:03 0000-00-00 00:00:00 2020 0 0 Str. 740-762 št. 6 Letn. 44 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2020-02-17 2020-07-12 2020-09-29 579 31111427 10.1093/femsre/fuaa029 0168-6445 Lee-2020-Why__-_Successful__i_Pseudomonas__i_.pdf Lee-2020-Why__-_Successful__i_Pseudomonas__i_.pdf 1 C3BAAEFA712CD1DDEA3ABA65A6C3B1E2 8c9bbbaa710546bb7c14ddead7a587ad28a648876c76a167eeb54722549faf13 2418162d-dd54-11ef-9187-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=188192 https://doi.org/10.1093/femsre/fuaa029 0 3120458a-dd54-11ef-9187-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=188193 Fakulteta za naravoslovje in matematiko 0 0 0