20.500.12556/DKUM-91695 Presaditev trebušne slinavke indikacija, kirurška tehnika, klinični pomen Pancreas transplantation indications, surgical technique, and clinical significance Presaditev trebušne slinavke je zlati standard za zdravljenje ledvične odpovedi pri bolnikih s sladkorno boleznijo oz. pri bolnikih s sladkorno boleznijo, kjer kljub intenzivirani inzulinski terapiji ne uspemo preprečiti nastanka kroničnih zapletov sladkorne bolezni. Z napredkom kirurgije in novimi imunosupresivnimi zdravili je v zadnjih desetletjih prišlo do bistvenega izboljšanja preživetja bolnikov in presadkov ter povečane kakovosti življenja po presaditvi. Presaditev trebušne slinavke je danes metoda izbire, s katero nadomestimo endokrino funkcijo trebušne slinavke, vzpostavimo normoglikemijo in preprečimo nastanek sekundarnih zapletov sladkorne bolezni. Med presaditve trebušne slinavke prištevamo sočasno presaditev trebušne slinavke in ledvice, presaditev samo trebušne slinavke, presaditev dela trebušne slinavke ter presaditev otočkovtrebušne slinavke. Enoletno preživetje bolnikov po presaditvi trebušne slinavke znaša 96 %, petletno pa 80 %. Preživetje je najbolj optimalno pri sočasni presaditvi trebušne slinavke in ledvice. Pancreas transplantation (PT) is a vital therapeutic option for patients with diabetes mellitus (DM)|, particularly those with end-stage renal disease (ESRD) or severe metabolic complications. Over the past several decades, advancements in surgical techniques, organ preservation and procurement methods, and immunosuppression therapies have significantly enhanced post-transplant patient survival, graft survival, and quality of life. The primary goals of PT are to achieve effective and stable glycemic control, often leading to insulin independence, improve the patient’s quality of life, and reduce secondary complications associated with DM. PT encompasses a variety of procedures, including PT alone from a living donor, whole PT, pancreas with kidney transplantation, and pancreatic islet cell transplantation. PT is most commonly performed in conjunction with kidney transplantation for selected patients with DM and ESRD. Over the past decade, unadjusted patient survival rates have exceeded 96% at 1-year post-transplant and >80% at 5 years. pancreas transplantation diabetes mellitus glycemic control simultaneous pancreas-kidney transplantation presaditev trebušne slinavke sladkorna bolezen normoglikemija simultana presaditev trebušne slinavke in ledvic true true true Angleški jezik Slovenski jezik Znanstveno delo 2025-01-28 14:10:45 2025-01-28 14:15:23 2026-03-18 13:26:28 0000-00-00 00:00:00 2024 0 0 str. 18-23 št. 2 Letn. 17 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 2024-11-13 2024-12-05 616.3 220448515 10.18690/actabiomed.277 1855-5640 RAZ_Hladnik_Gaja_2024.pdf RAZ_Hladnik_Gaja_2024.pdf 1 E0EAE621FADE28986D2CC2A4078AB09C 0229cd7a323af418f820062aade974ecfe4c6a23c11ab4b973201c91fcff2520 994e7fd1-dd79-11ef-9187-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=188225 https://doi.org/10.18690/actabiomed.277 0 a0d54663-de0d-11ef-9dfa-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=188261 https://journals.um.si/index.php/amb/article/view/4758 1 4aee8b0d-dd79-11ef-9187-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=188224 Medicinska fakulteta Acta medico-biotechnica 0 0 0