20.500.12556/DKUM-91760 Mapping active pharmaceutical ingredients distributions in tablets using time-of-flight secondary ion mass spectrometry with multivariate curve resolution This study introduces an advanced approach to identifying signals associated with indapamide, amlodipine, and perindopril in solid dosage form using time-of-flight secondary ion mass spectrometry (ToF-SIMS) combined with multivariate curve resolution (MCR). The primary objective was to obtain and characterize these signals through MCR factors, which then led to identifying unique signals specific to each active pharmaceutical ingredient (API). These unique signals were crucial for constructing detailed 2D and 3D images of the API distribution within the tablet. The results demonstrated that indapamide and amlodipine exhibited multiple unique peaks, while perindopril had only one. Additionally, the study revealed non-homogeneous distribution patterns of APIs and excipients, such as SiO2 and Mg stearate. This work highlights the significance of applying advanced analytical techniques such as ToF-SIMS and MCR in the pharmaceutical field to ensure consistent therapeutic efficacy through a better understanding of API distribution. Tof-SIMS MVSA MCR indapamide amlodipine perindopril farmacevtske sestavine masna spektrometrija true true false Elsevier Angleški jezik Slovenski jezik https://www.sciencedirect.com/science/article/pii/S0026265X24022689?via%3Dihub © 2024 The Author Članek v reviji 2025-02-03 13:44:31 2025-02-03 13:44:31 2025-02-04 03:11:10 0000-00-00 00:00:00 2024 0 0 8 str. Vol. 207, [article no.] 112156 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-11-06 2024-11-08 2024-11-10 544.5/.6 215675395 10.1016/j.microc.2024.112156 1095-9149 1-s2.0-S0026265X24022689-main.pdf 1-s2.0-S0026265X24022689-main.pdf 1 34281576CBABE136C4662136A12B5E14 6dcd21a45528627c2c8fb530bc297ba8dfe9b1199ba1232d7633c1d128cfcd95 dc9a22e4-e22c-11ef-9425-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=188403 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0