20.500.12556/DKUM-91855 In silico characterization of sirtuins in acetic acid bacteria reveals a novel phylogenetically distinctive group Acetic acid bacteria are single-celled organisms well-known for their ability to convert ethanol into acetic acid. Still, recent research suggests they may harbor another attractive characteristic - the production of proteins with remarkable similarities to sirtuins. Sirtuins have been linked to lifespan extension in various organisms, raising intriguing questions about the potential connection between acetic acid bacteria and the biology of aging. This article delves into the characterization of sirtuin homologs in acetic acid bacteria. Up to three types of sirtuin homologs have been identified in 21% of acetic acid bacteria genomes deposited in NCBI. All three types were present only in the genera Acetobacter and Novacetimonas, which are known to survive in the harshest environmental conditions (high concentrations of acetic acid and ethanol). Interestingly, two types of these sirtuin homologs (SirAAB-L and SirAAB-S) constitute a separate group (SirAAB), distinctive from all other presently known sirtuins. The results obtained in silico thus encourage further studies into the function of these types of sirtuins and their interplay with metabolic pathways in these industrially important bacteria. acetic acid bacteria Acetobacter Novacetimonas aging sirtuins SirAAB SirAAB-L SirAAB-S ocetnokislinske bakterije Acetobacter sirtuini true false true Angleški jezik Slovenski jezik Znanstveno delo 2025-02-14 07:50:19 2025-02-14 08:10:38 2025-02-15 03:11:22 0000-00-00 00:00:00 2025 0 0 str. 1-27 št. 3, št. članka 635 Letn. 30 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-08-23 2025-01-28 2025-01-31 579.6 225796099 10.3390/molecules30030635 1420-3049 RAZ_Jugovic_Igor_2025.pdf RAZ_Jugovic_Igor_2025.pdf 1 C8FABB0F0279B67C163B39A5FFFF0C2D e98109e30a4430f08fdf9229ccefedc2a5edf5e4095c3fb7076be10a3378d842 5b76853c-eaa2-11ef-bdc3-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=188658 https://www.mdpi.com/1420-3049/30/3/635 1 f6100b56-ea9f-11ef-bdc3-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=188657 Fakulteta za naravoslovje in matematiko 0 0 0