20.500.12556/DKUM-91871 Učinek rdečega kvasnega riža pri uravnavanju hiperholesterolemij The effect of red yeast rice in regulation of hypercholesterolemia Uvod: Hiperholesterolemija predstavlja pomemben javnozdravstveni izziv, saj povečuje tveganje za srčno-žilne bolezni, ki so glavni vzrok smrti po vsem svetu. Zdravljenje običajno temelji na farmakoloških pristopih, kot so statini, vendar ti pogosto povzročajo neželene učinke. Rdeč kvasni riž (RYR), uveljavljen kot naravni prehranski dodatek, vsebuje monakolin K, ki je strukturno enak lovastatinu. Namen raziskave je bil raziskati možnost obvladovanja hiperholesterolemij z uživanjem rdečega kvasnega riža, ki je predstavljen kot alternativa vsem dobro poznanim statinom. Metode: Zaključno delo je napisano na podlagi deskriptivne metode dela. Relevantno strokovno literaturo smo pridobili, analizirali oziroma pregledali iz naslednjih mednarodnih priznanih podatkovnih baz: PubMed, Sage, ScienceDirct, CINAHL Ultimate. Izvedli smo pregled literature, ki smo jo predstavili s pomočjo PRISMA diagrama. Rezultati: V raziskavo smo vključili sedem randomiziranih kliničnih raziskav, ki so pokazale, da RYR pomembno znižuje holesterol LDL, skupni holesterol in trigliceride z minimalnimi neželenimi učinki. Učinkovitost se poveča v kombinaciji z drugimi spojinami, kot sta berberin in polifenoli. Zaključek: Rdeč kvasni riž predstavlja obetavno naravno alternativo za obvladovanje hiperholesterolemij. Njegova širša uporaba zahteva nadaljnje raziskave in večjo ozaveščenost javnosti o njegovih prednostih. Introduction: Hypercholesterolaemia is a major public health challenge, increasing the risk of cardiovascular disease, the leading cause of death worldwide. Treatment is usually based on pharmacological approaches such as statins, but these often cause side effects. Red yeast rice (RYR) established as a natural food supplement contains monacolin K, structurally identical to lovastatin. The aim of this study was to investigate the possibility of managing hypercholesterolaemia by consuming red yeast rice, which is presented as an alternative to all well-known statins. Methods: Relevant literature was retrieved, analysed or reviewed from the following internationally recognised databases: PubMed, Sage, ScienceDirct, CINAHL Ultimate. A literature review was performed and presented using the PRISMA diagram. Results: We included seven randomised clinical trials that showed that RYR significantly lowers cholesterol LDL, total cholesterol and triglycerides, with minimal side effects. Efficiency is increased when combined with other compounds such as berberine and polyphenols. Conclusion: Red yeast rice represents a promising natural alternative for the management of hypercholesterolaemia. It's wider use requires further research and greater public awareness of its benefits. rdeč kvasni riž statini hiperholesterolemija lipidi zdrav življenjski slog red yeast rice statins hypercholesterolemia lipids healthy lifestyle true true false [K. Bevc] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-02-17 17:19:59 2025-05-06 09:08:34 2025-05-27 14:44:13 0000-00-00 00:00:00 2025 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.153.922:615.272(043.2) 232185603 VS_Bevc_Katarina_2025.pdf VS_Bevc_Katarina_2025.pdf 1 E4D7E8B318B3B7355A225018FD5A83A8 9b66372721c43b69c9627b9c7c06f25baa1ca6dd98365927d156edc5fbb98980 f9b74f2b-ed4c-11ef-9ff5-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=188707 Fakulteta za zdravstvene vede 0 0 0