20.500.12556/DKUM-91881 Vpliv prekinitvenega posta na sladkorno bolezen tipa 2: mehanizmi, učinki in možnost terapevtske uporabe The impact of intermittent fasting on type 2 diabetes: mechanisms, effects and potential therapeutic applications Uvod: Sladkorna bolezen tipa 2 je ena najpogostejših kroničnih bolezni. Za obvladovanje le-te so bistveni prehranski ukrepi. Prekinitveni post je postal prepoznaven kot metoda za izboljšanje presnovnega zdravja. Namen zaključnega dela je raziskati učinke in mehanizme delovanja ter možnosti terapevtke uporabe prekinitvenega posta pri osebah s sladkorno boleznijo tipa 2. Metode: Izvedli smo sistematični pregled literature v podatkovnih bazah PubMed, Web of Science, CINAHL Ultimate (EBSCOhost) in SAGE. Za prikaz poteka vključitve raziskav smo uporabili PRISMA diagram. Rezultate raziskav smo prikazali v tabeli in članke kritično ocenili po JBI. Sinteza je bila izvedena z opisno metodo dela. Rezultati: V končno analizo je bilo vključenih 16 raziskav; deset randomiziranih kliničnih raziskav in šest pregledov literature. Vključene so bile različne metode prekinitvenega posta. Večina vključenih raziskav poroča o znižanju telesne mase ob upoštevanju prekinitvenega posta. Ugotavljamo, da ima prekinitveni post pozitivne učinke na ravni HbA1c, urejenost glikemije in inzulinsko rezistenco, vendar so rezultati primerljivi z neprekinjenim omejevanjem energijskega vnosa. Razprava in zaključek: Prekinitveni post ugodno vpliva na znižanje telesne mase in urejenost glikemije in bi lahko bil uporaben kot prehranski pristop pri obvladovanju sladkorne bolezni tipa 2. Introduction: Type 2 diabetes is one of the most common chronic diseases. Nutritional interventions are essential for its management. Intermittent fasting has become recognized as a method for improving metabolic health. The aim of this thesis is to investigate the effects, mechanisms, and potential therapeutic applications of intermittent fasting in people with type 2 diabetes. Methods: We conducted a systematic literature review using the databases PubMed, Web of Science, CINAHL Ultimate (EBSCOhost), and SAGE. The PRISMA diagram were used to present the study selection process. The research results were presented in a table, and articles were critically evaluated according to JBI criteria. Synthesis was performed using a descriptive approach. Results: Sixteen studies were included in the final analysis: ten randomized clinical trials and six literature reviews. Various methods of intermittent fasting were included. Most of the involved studies reported weight loss with intermittent fasting. We found that intermittent fasting positively affects HbA1c levels, glycemic control, and insulin resistance; however, these results are comparable to those achieved with continuous caloric restriction. Discussion and conclusion: Intermittent fasting has a beneficial effect on weight loss and glycemic control and could be used as a dietary approach in the management of type 2 diabetes. prekinitveni post sladkorna bolezen tipa 2 krvni sladkor telesna masa intermittent fasting diabetes type 2 blood glucose body weight true true false [U. Špegel] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2025-02-20 21:06:55 2025-05-06 09:04:42 2025-05-27 14:38:40 0000-00-00 00:00:00 2025 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.379-008.64:612.391(043.2) 232145667 MAG_Spegel_Urska_2025.pdf MAG_Spegel_Urska_2025.pdf 1 A5585D072B75B4007269E367082E6B47 531668189d51010c32e925c5a234f03829e302e218fc2d4b96ee0387ab335e79 49b40816-efc7-11ef-8390-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=188752 Fakulteta za zdravstvene vede 0 0 0