20.500.12556/DKUM-92146 Ketoprofen-loaded PLGA-based bioactive coating prepared by supercritical foaming on a TiAl6V4 substrate for local drug delivery in orthopedic applications In this study, a novel biodegradable poly(lactic-co-glycolic) acid coating containing a model anti-inflammatory drug (ketoprofen) was prepared on TiAl6V4 substrate for use in orthopedic medicine by a two-step process combining drop casting and supercritical CO2-assisted foaming. The prepared coating was first investigated by surface analysis techniques using time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy. The combined results confirmed the loading of ketoprofen and its homogeneous spatial distribution in the coating. 3D profilometry revealed increased surface roughness of the coating compared to the bare TiAl6V4 substrate, which is favorable for cell adhesion. Furthermore, the electrochemical measurements (i.e., electrochemical impedance spectroscopy and potentiodynamic curve measurements) demonstrated that the coating application significantly mitigated corrosion compared to the bare TiAl6V4 substrate. In vitro drug release tests revealed extended drug release in simulated body fluids with zero-order release kinetics. Finally, the promising cell testing results using adipose-derived mesenchymal stem cells and osteoblasts confirmed the applicability of the coating for implants. Overall, the results of this study highlight the significant potential of the developed bioactive coating for future orthopedic applications. TiAlV bioactive coating implants PLGA supercritical foaming ketoprofen bioaktivni premazi superkritično penjenje vsadki true true false Angleški jezik Slovenski jezik https://www.sciencedirect.com/science/article/pii/S0300944023006227?via%3Dihub © 2023 The Author(s) Neznano 2025-03-14 11:48:42 2025-03-14 11:48:42 2025-03-15 03:10:38 0000-00-00 00:00:00 2024 0 0 11 str. [article no.] 108026 Vol. 186 Jan. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-10-01 2023-10-08 2023-10-16 620.1/.2 168679171 10.1016/j.porgcoat.2023.108026 1873-331X 1-s2.0-S0300944023006227-main.pdf 1-s2.0-S0300944023006227-main.pdf 1 1034AD9967D02E056EA60729F2A5C714 2ed887a40a34852000fcad9af56be39ef94d9dc8a977c6e17977cfc55a7e6cb8 3b43050a-00c2-11f0-9c63-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=189362 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0