20.500.12556/DKUM-92183 Critical transitions in pancreatic islets Calcium signals in pancreatic � cell collectives show a sharp transition from uncorrelated to correlated state resembling a phase transition as the slowly increasing glucose concentration crosses the tipping point. However, the exact nature or the order of this phase transition is not well understood. Using confocal microscopy to record the collective calcium activation of � cells in an intact islet under changing glucose concentration in an increasing and then decreasing way, we first show that in, addition to the sharp transition, the coordinated calcium response exhibits a hysteresis indicating a critical, first-order transition. A network model of � cells combining link selection and coordination mechanisms capture the observed hysteresis loop and the critical nature of the transition. Our results point towards an understanding of the role of islets as tipping elements in the pancreas that, interconnected by perfusion, diffusion, and innervation, cause the tipping dynamics and abrupt insulin release. cellular organization physiology & dynamics phase transitions in biological systems complex networks endocrine system optical microscopy true true true APS Angleški jezik Angleški jezik Znanstveno delo 2025-03-19 09:32:17 2025-03-19 09:41:17 2025-03-20 03:10:47 0000-00-00 00:00:00 2025 0 0 Str. 1-7 št. 3, št. članka 034405 Letn. 111 Marec 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-11-16 2025-01-22 2025-03-12 612 229170179 10.1103/PhysRevE.111.034405 2470-0053 RAZ_Korosak_Dean_2025.pdf RAZ_Korosak_Dean_2025.pdf 1 F51710633536E124A989A942C337B17B e187b07f91df60b8e3a693f2c07654709fe0c6247652cd06f9d261add8d8cd0c 8ecc83a8-049d-11f0-a5c9-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=189467 https://doi.org/10.1103/PhysRevE.111.034405 0 d1ae2412-049d-11f0-a5c9-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=189468 https://journals.aps.org/pre/abstract/10.1103/PhysRevE.111.034405#abstract 1 aea93248-049c-11f0-a5c9-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=189466 Medicinska fakulteta 0 0 0