20.500.12556/DKUM-92279 Bromelain and nisin: The natural antimicrobials with high potential in biomedicine Infectious diseases along with various cancer types are among the most significant public health problems and the leading cause of death worldwide. The situation has become even more complex with the rapid development of multidrug-resistant microorganisms. New drugs are urgently needed to curb the increasing spread of diseases in humans and livestock. Promising candidates are natural antimicrobial peptides produced by bacteria, and therapeutic enzymes, extracted from medicinal plants. This review highlights the structure and properties of plant origin bromelain and antimicrobial peptide nisin, along with their mechanism of action, the immobilization strategies, and recent applications in the field of biomedicine. Future perspectives towards the commercialization of new biomedical products, including these important bioactive compounds, have been highlighted. bromelain nisin bioactivity antimicrobial agent biomedicine carrier protimikrobna sredstva biomedicina nosilec true false true MDPI AG Angleški jezik Slovenski jezik https://www.mdpi.com/journal/pharmaceutics © 2021 by the authors Članek v reviji 2025-03-27 07:40:41 2025-03-27 07:40:41 2025-03-28 03:10:31 0000-00-00 00:00:00 2022 0 0 str. 1-39 iss. 1 Vol. 14 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2021-11-22 2021-12-23 2021-12-29 577:543.2/.9 91691779 10.3390/pharmaceutics14010076 1999-4923 pharmaceutics-14-00076.pdf pharmaceutics-14-00076.pdf 1 574954CA2D5E9422B1E020C2715DE0B9 752efe52d744ded0807c7d4a82ebd98a77c73918b344f22a611b790410266792 a216c726-0ad6-11f0-8bc4-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=189698 https://www.mdpi.com/1999-4923/14/1/76 0 a89c564a-0ad6-11f0-8bc4-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=189699 Fakulteta za strojništvo 0 0 0