20.500.12556/DKUM-92390 Diagnosis, clinical presentation and management of celiac disease in children and adolescents in Poland Celiac disease (CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals, affecting about 1% of the general population in the developed world. In 2012, the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) recommendations for CD diagnoses in children and adolescents were introduced, allowing the “no-biopsy” approach if certain criteria were met. This approach was also confirmed in the revised guidelines published in 2020. Thus, the aim of this study was to assess—over a one-year period—the clinical presentations and current status of the management of children and adolescents diagnosed with CD in Poland. Medical records of children and adolescents, newly diagnosed with CD in 2022/2023 in three medical centers in Poland, were involved. Gastroenterologists completed the specific anonymous web-based forms developed in the CD SKILLS project, including data routinely assessed at individual visits about the diagnostic approach and clinical presentation of the disease. Our study assessed 100 patients (56% girls) with an age range 1.6–18.0 years. We found that 98% of patients were serologically tested prior to a CD diagnosis and 58% of patients were diagnosed using the “no-biopsy” approach. In the analyzed group, 40% belonged to a known risk group, only 22% had annual screening before the CD diagnosis (the longest for 9 years), and 19% showed no symptoms at the time of the CD diagnosis. Our research confirmed the applicability of the “no-biopsy” approach for the diagnosis of CD in children and adolescents in Poland, and also showed changes in the clinical picture of CD. Moreover, we highlight the need to introduce broad CD serological screening in risk groups of the Polish population. celiac disease no-biopsy risk groups Polish population celiakija brez biopsije skupine tveganja Poljska true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2025-04-04 09:09:55 2025-04-04 09:37:02 2025-04-05 03:07:44 0000-00-00 00:00:00 2024 0 0 Str. 1-13 št 3, št. članka 765 Letn. 13 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-11-30 2024-01-25 2024-01-26 616.3 183226115 10.3390/jcm13030765 2077-0383 Birela_2024_Diagnosis_Clinical_Presentation_and_Management.pdf Birela_2024_Diagnosis_Clinical_Presentation_and_Management.pdf 1 3E9470EFF20D2A9E199027C2BB583ED2 dd2ec4959c2dc3d4020471c981f4f0234ad829a05049bed4cb7f0b6b23349aef 7749822a-1127-11f0-b51c-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=189983 https://doi.org/10.3390/jcm13030765 1 d1342375-1123-11f0-b51c-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=189982 Medicinska fakulteta 0 0 0