20.500.12556/DKUM-92421 Ranking as a procedure for selecting a replacement variable in the score predicting the survival of patients treated with curative intent for colorectal liver metastases Background and Objectives: The issue of a missing variable precludes the external validation of many prognostic models. For example, the Liverpool score predicts the survival of patients undergoing surgical therapy for colorectal liver metastases, but it includes the neutrophil–lymphocyte ratio, which cannot be measured retrospectively. Materials and Methods: We aimed to find the most appropriate replacement for the neutrophil–lymphocyte ratio. Survival analysis was performed on data representing 632 liver resections for colorectal liver metastases from 2000 to 2020. Variables associated with the Liverpool score, C-reactive protein, albumins, and fibrinogen were ranked. The rankings were performed in four ways: The first two were based on the Kaplan-Meier method (log-rank statistics and the definite integral �� between two survival curves). The next method of ranking was based on univariate and multivariate Cox regression analyses. Results: The ranks were as follows: the radicality of liver resection (rank 1), lymph node infiltration of primary colorectal cancer (rank 2), elevated C-reactive protein (rank 3), the American Society of Anesthesiologists Classification grade (rank 4), the right-sidedness of primary colorectal cancer (rank 5), the multiplicity of colorectal liver metastases (rank 6), the size of colorectal liver metastases (rank 7), albumins (rank 8), and fibrinogen (rank 9). Conclusions: The ranking methodologies resulted in almost the same ranking order of the variables. Elevated C-reactive protein was ranked highly and can be considered a relevant replacement for the neutrophil–lymphocyte ratio in the Liverpool score. These methods are suitable for ranking variables in similar models for medical research. colorectal cancer liver metastases inflammation ranking survival kolorektalni rak metastaze v jetrih vnetja razvrščanje preživetje true false true MDPI Angleški jezik Slovenski jezik Znanstveno delo 2025-04-07 15:11:13 2025-04-07 15:20:31 2025-04-08 03:10:00 0000-00-00 00:00:00 2023 0 0 Str. 1-13 št. 1, št. članka 2003 Letn. 59 Nov. 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-10-16 2023-11-13 2023-11-15 616.36-006 172746243 10.3390/medicina59112003 1648-9144 Plahuta_2023_Ranking_as_a_Procedure_for_Selecting.pdf Plahuta_2023_Ranking_as_a_Procedure_for_Selecting.pdf 1 BEAB34B7FCC5601FBBD5335702F8BEB4 9b1bd15680f3ee8a04eaf3cde107675bb02ee7f669e67eacc0cde4072bf6e359 f6a47a81-13b2-11f0-9c98-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=190076 https://doi.org/10.3390/medicina59112003 1 c91277f9-13b1-11f0-9c98-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=190074 Medicinska fakulteta Fakulteta za gradbeništvo, prometno inženirstvo in arhitekturo 0 0 0