20.500.12556/DKUM-92446 Addressing the needs of the rapidly aging society through the development of multifunctional bioactive coatings for orthopedic applications The unprecedented aging of the world’s population will boost the need for orthopedic implants and expose their current limitations to a greater extent due to the medical complexity of elderly patients and longer indwelling times of the implanted materials. Biocompatible metals with multifunctional bioactive coatings promise to provide the means for the controlled and tailorable release of different medications for patient-specific treatment while prolonging the material’s lifespan and thus improving the surgical outcome. The objective of this work is to provide a review of several groups of biocompatible materials that might be utilized as constituents for the development of multifunctional bioactive coatings on metal materials with a focus on antimicrobial, pain-relieving, and anticoagulant properties. Moreover, the review presents a summary of medications used in clinical settings, the disadvantages of the commercially available products, and insight into the latest development strategies. For a more successful translation of such research into clinical practice, extensive knowledge of the chemical interactions between the components and a detailed understanding of the properties and mechanisms of biological matter are required. Moreover, the cost-efficiency of the surface treatment should be considered in the development process. biomaterials orthopedic implants multifunctional coatings drug delivery antimicrobial pain relief biomateriali ortopedski implantanti dostava zdravil lajšanje bolečin večnamenski premazi true false true MDPI Angleški jezik Slovenski jezik https://www.mdpi.com/journal/ijms © 2022 by the authors Članek v reviji 2025-04-09 13:25:11 2025-04-09 13:25:11 2025-04-10 03:08:34 0000-00-00 00:00:00 2022 0 0 35 str. no. 5 Vol. 23 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2022-02-15 2022-02-28 2022-03-03 577 99561219 10.3390/ijms23052786 1422-0067 ijms-23-02786-v2.pdf ijms-23-02786-v2.pdf 1 36012842967AD70A60B7B11E2EC5AD31 5ce5e3f120e2fc32b67e074dec894b74d98b08a98acf314d619f39b08f292c29 dd2784c3-1535-11f0-b793-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=190139 https://www.mdpi.com/1422-0067/23/5/2786 1 4d06a08d-1535-11f0-b793-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=190138 Fakulteta za kemijo in kemijsko tehnologijo Medicinska fakulteta 0 0 0